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Titolo:
Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice
Autore:
Borowicz, KK; Stasiuk, G; Teter, J; Kleinrok, Z; Gasior, M; Czuczwar, SJ;
Indirizzi:
Lublin Med Univ Sch, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland Lublin Med Univ Sch Lublin Poland PL-20090 icol, PL-20090 Lublin, Poland Inst Agr Med, Dept Clin Toxicol, Lublin, Poland Inst Agr Med Lublin Poland t Agr Med, Dept Clin Toxicol, Lublin, Poland
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 7, volume: 107, anno: 2000,
pagine: 733 - 743
SICI:
0300-9564(2000)107:7<733:LPOCAD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICONVULSANT ACTIVITY; PRESURGICAL EVALUATION; PROTECTIVE EFFICACY; CARBAMAZEPINE; DISCONTINUATION; METABOLITES; POLYTHERAPY; VALPROATE; TRIAL; ACID;
Keywords:
felbamate; antiepileptic drugs; electroshock maximal; drug interactions; seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Czuczwar, SJ Lublin Med Univ Sch, Dept Pharmacol & Toxicol, Jaczewskiego 8, PL-20090 Lublin, Poland Lublin Med Univ Sch Jaczewskiego 8 Lublin PolandPL-20090 nd
Citazione:
K.K. Borowicz et al., "Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice", J NEURAL TR, 107(7), 2000, pp. 733-743

Abstract

The objective of this study was to evaluate an interaction of the novel antiepileptic drug felbamate (2-phenyl-1,3-propanediol dicarbamate) with conventional antiepileptic drugs against maximal electroshock-induced convulsions in mice. Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the endpoint). Adverse effects were evaluated in the chimney test (motor performance) and passive avoidance task (long-term memory). Brain and plasma levels of antiepileptic drugs were measured by immunofluorescence. Felbamate (7.5-30 mg/kg) significantly increased the electroconvulsive threshold. Felbamate at the subprotective dose of 5 mg/kg did not affect theanticonvulsive action of antiepileptics studied. On the other hand, this drug used at the lowest protective dose of 7.5 mg/kg remained without effectupon the activity of valproate, carbamazepine or phenobarbital, but significantly potentiated the protective potential of diphenylhydantoin. No adverse effects were observed with combinations of felbamate with these antiepileptics. Neither brain nor free plasma levels of antiepileptic drugs were changed by felbamate. The results indicate that the combination of felbamate with conventional antiepileptic drugs is not promising from the experimental point of view.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:46:34