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Titolo:
Increased frequency of surface IgA-positive plasma cells in the intestinallamina propria and decreased IgA excretion in hyper IgA, (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA
Autore:
Kamata, T; Nogaki, F; Fagarasan, S; Sakiyama, T; Kobayashi, N; Miyawaki, S; Ikuta, K; Muso, E; Yoshida, H; Sasayama, S; Honjo, T;
Indirizzi:
Kyoto Univ, Fac Med,Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Dept Internal Med, Div 3, Kyoto, Japan Kyoto Univ Kyoto Japan oto Univ, Dept Internal Med, Div 3, Kyoto, Japan Nippon Shinyaku Co Ltd, Res Labs, Kyoto 601, Japan Nippon Shinyaku Co LtdKyoto Japan 601 o Ltd, Res Labs, Kyoto 601, Japan Kitano Hosp, Med Res Inst, Div Nephrol, Osaka, Japan Kitano Hosp Osaka Japan o Hosp, Med Res Inst, Div Nephrol, Osaka, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 165, anno: 2000,
pagine: 1387 - 1394
SICI:
0022-1767(20000801)165:3<1387:IFOSIP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR EXTRACELLULAR-MATRIX; LY-1 B-CELLS; DDY MICE; IMMUNOGLOBULIN-A; TRANSGENIC MICE; SERUM IGA; PERITONEAL-CAVITY; DEFICIENT MICE; LYMPHOCYTES-B; J-CHAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Honjo, T Kyoto Univ, Fac Med,Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 , Sakyo Ku, Kyoto 6068501, Japan
Citazione:
T. Kamata et al., "Increased frequency of surface IgA-positive plasma cells in the intestinallamina propria and decreased IgA excretion in hyper IgA, (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA", J IMMUNOL, 165(3), 2000, pp. 1387-1394

Abstract

Because abnormalities of mucosal immunity have been suggested in human IgAnephropathy, we examined the involvement of mucosal immunity in IgA deposition to the kidney in hyper IgA (HIGA) mice, which was established as a mouse model for human IgA nephropathy with hyperserum IgA, The number of surface IgA(+)B220(-) lymphocytes in the intestinal lamina propria (LP) of HIGA mice increased 2.7-fold at 30 wk of age as compared with those at 10 wk of age, whereas normal mice did not show such increase. The surface IgA(+)B220(-) LP lymphocytes spontaneously secreted IgA in culture, Morphological studies showed that the surface IgA(+)B220(-) lymphocytes of murine intestinalLP are identical with plasma cells (PCs), About 20% of IgA(+)B220(-) PC inLP expressed both Mac-1 and CD19, suggesting that they may derive from peritoneal B-l cells, Cell cycle study on intestinal IgA-PCs using bromodeoxyuridine revealed no difference between HIGA mice and normal mice, suggestingthat the high frequency of IgA-producing PCs in HIGA mice is not due to enhanced proliferation or prolonged survival of IgA-producing PCs in LP, In addition, IgA secretion into the gut lumen of HIGA mice decreased drastically (to one forth) with aging. These data suggest that the increased number of intestinal IgA-producing PCs and the down-regulation of IgA excretion into the intestinal lumen might synergistically contribute to the hyperserum IgA in HIGA mice and resultant IgA deposition to the kidney.

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Documento generato il 20/01/20 alle ore 22:01:10