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Titolo:
Levels of nerve growth factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo
Autore:
Harrison, SMW; Jones, ME; Uecker, S; Albers, KM; Kudrycki, KE; Davis, BM;
Indirizzi:
Univ Kentucky, Coll Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Coll Med, Dept Pathol & Lab Med, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 l & Lab Med, Lexington, KY 40536 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 424, anno: 2000,
pagine: 99 - 110
SICI:
0021-9967(20000814)424:1<99:LONGFA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; RECEPTOR GENE-EXPRESSION; SENSORY NEURONS; IN-VIVO; CUTANEOUS MECHANORECEPTORS; MOLECULAR-CLONING; TRK RECEPTORS; HIGH-AFFINITY; MICE LACKING; SURVIVAL;
Keywords:
neurotrophin; neurotrophin receptor; tyrosine receptor kinase; transgenic mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, BM Univ Kentucky, Coll Med, Dept Anat & Neurobiol, 800 Rose St,MN224, Lexington, KY 40536 USA Univ Kentucky 800 Rose St,MN224 Lexington KY USA40536 40536 USA
Citazione:
S.M.W. Harrison et al., "Levels of nerve growth factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo", J COMP NEUR, 424(1), 2000, pp. 99-110

Abstract

The development and survival of sympathetic neurons is critically dependent on the related neurotrophic factors nerve growth factor (NGF) and neurotrophin-3 (NT3), the actions of which must be executed appropriately despite spatial and temporal overlaps in their activities. The tyrosine receptor kinases, trkA. and trkC, are the cognate receptors for NGF and NT3, respectively. The p75 neurotrophin receptor has been implicated in neurotrophin binding and signaling for both NGF and NT3. In this study, the authors used mice that overexpressed NGF (NGF-OE) or NT3 (NT3-OE) in skin and mice that lacked p75 (p75(-/-)) to understand the dynamics of sympathetic neuron response to each neurotrophin and to address the role of p75. NGF and NT3 were measured in sympathetic ganglia and skin (a major target of sympathetic neurons) by using the enzyme-linked immunosorbent assay (ELISA) technique. A three- to four-fold increase in skin NT3 was seen in both NT3-OE and p75(-/-) mice. Moreover, both mouse lines exhibited a three-fold increase in ganglionic NT3. However, the increase in ganglionic NT3 was accompanied by a decrease in ganglionic NGF in p75(-/-) mice but not in NT3-OE mice. This indicated that p75 plays an important role in determining the level of NGF within sympathetic neurons. In NGF-OE mice, the overexpression of NGF was correlated with increased ganglionic NGF and increased ganglionic expression of p75 mRNA. In addition, in NGF-OE mice, ganglionic trkC expression was decreased, as was the amount of NT3 present within sympathetic ganglia. These results indicate that the level of p75 is integral in determining the level of sympathetic NGF and that NGF competes with NT3 by increasing the expression of p75 and decreasing the expression of trkC. J. Comp. Neurol. 424:99-110, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:16:00