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Titolo:
Expression of corticotropin-releasing hormone messenger ribonucleic acid in human pituitary corticotroph adenomas associated with proliferative potential
Autore:
Xu, B; Sano, T; Yamada, S; Li, CC; Hirokawa, M;
Indirizzi:
Univ Tokushima, Sch Med, Dept Pathol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 Pathol, Tokushima 7708503, Japan Toranomon Gen Hosp, Dept Neurosurg, Tokyo 1050001, Japan Toranomon Gen Hosp Tokyo Japan 1050001 t Neurosurg, Tokyo 1050001, Japan
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 85, anno: 2000,
pagine: 1220 - 1225
SICI:
0021-972X(200003)85:3<1220:EOCHMR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA INHIBITORY FACTOR; CUSHINGS-DISEASE; ANTERIOR-PITUITARY; ADRENOCORTICOTROPIN SECRETION; P27(KIP1) EXPRESSION; TUMORS; RECEPTOR; CARCINOMA; MUTATIONS; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, B Univ Tokushima, Sch Med, Dept Pathol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 l, Tokushima 7708503, Japan
Citazione:
B. Xu et al., "Expression of corticotropin-releasing hormone messenger ribonucleic acid in human pituitary corticotroph adenomas associated with proliferative potential", J CLIN END, 85(3), 2000, pp. 1220-1225

Abstract

Among the factors that promote the growth of human pituitary corticotroph adenomas (hPCAs), the proliferative potential of CRH secreted by hPCAs on these tumors is not well known. In this study, the CRH messenger ribonucleicacid (mRNA) transcripts were demonstrated on paraffin sections using the quantitative in situ hybridization method in 37 of 43 hPCAs, including 17 of22 microadenomas, 15 of 15 macroadenomas, and 5 of 6 locally invasive adenomas according to Hardy's classification of pituitary adenomas. The more important findings were that CRH mRNA signal intensity in pituitary corticotroph adenoma cells was linearly correlated with Ki-67 tumor growth fractions(r = 0.802; P < 0.0001), and in macroadenoma and locally invasive adenoma cells it was significantly higher than in microadenoma cells (P = 0.035). On the other hand, CRH mRNA transcript accumulation was absent or negligiblein 10 normal pituitary glands (P = 0.005). This is the first report of the frequent expression of CRH mRNA localized in human pituitary corticotroph adenoma cells. These results indicate that CRH from a local source of corticotroph adenoma cells not only has autocrine/paracrine functions in corticotroph adenomatous tissue, but also is an important factor associated with a proliferative potential of hPCAs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:45:17