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Titolo:
In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans
Autore:
Giltay, EJ; Fonk, JCM; von Blomberg, BME; Drexhage, HA; Schalkwijk, C; Gooren, LJG;
Indirizzi:
Free Univ Amsterdam Hosp, Div Androl, Dept Endocrinol, Res Inst EndocrinolReprod & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam HospAmsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Dept Pathol, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Dept Clin Chem, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Erasmus Univ, Dept Immunol, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 4, volume: 85, anno: 2000,
pagine: 1648 - 1657
SICI:
0021-972X(200004)85:4<1648:IVEOSS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-LUPUS-ERYTHEMATOSUS; NATURAL-KILLER CELLS; GROWTH-FACTOR-I; T-CELLS; CHEMOTACTIC RESPONSIVENESS; AUTOIMMUNE-THYROIDITIS; SUCCESSFUL PREGNANCY; CHEMOKINE RECEPTORS; ANDROGEN RECEPTORS; C57BL/6J MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Giltay, EJ Free Univ Amsterdam Hosp, Div Androl, Dept Endocrinol, Res InstEndocrinolReprod & Metab, POB 7057, NL-1007 MB Amsterdam, Netherlands FreeUniv Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay et al., "In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans", J CLIN END, 85(4), 2000, pp. 1648-1657

Abstract

The female predominance in several autoimmune diseases suggests a role forsex steroid hormones in disease susceptibility. We therefore investigated to what extent sex hormones would influence immune responsiveness. me analyzed T helper type 1 (T(H)1) and type 2 cytokine patterns, chemokine receptor expression (n = 2 x 10), and Ig levels (n = 2 x 25) in transsexual men and women before and after 4 months of cross-sex hormone administration. Antithyroperoxidase levels mere compared between 186 transsexual males (treated>5 yr with estrogens) and 186 male controls. In men, estrogens plus antiandrogens increased free cortisol levels in 24-h urine samples, decreased natural killer cell numbers, and slightly inhibited the mitogen-induced interferon-gamma/interleukin-4 ratio, but up-regulated the expression of T(H)1-associated chemokine receptors, CCR1, CXCR3, and CCR5, Conversely, in women, androgens slightly decreased free cortisol levels in 24-h urine samples and enhanced the mitogen-induced interferon-gamma/interleukin-4 ratio and tumor necrosis factor-alpha production. At the single cell level no T(H)1/T(H)2 shifts were found. Remarkably, up-regulationof T(H)1 cytokines was accompanied by down-regulation of CCR1, CXCR3, and CCR5 expression. Neither CD4(+) lymphocyte numbers nor IgG, IgM, and antithyroperoxidase levels, although higher in women then in men, were affected by cross-sex hormonal treatment. These results demonstrate that the capacity to develop a T(H)1 phenotype of peripheral blood lymphocytes is stimulated by androgens and is slightly inhibited by estrogens. These changes may be direct or indirect through the effects on other hormones.

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Documento generato il 04/12/20 alle ore 22:43:41