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Titolo:
Male-to-female transsexuals have female neuron numbers in a limbic nucleus
Autore:
Kruijver, FPM; Zhou, JN; Pool, CW; Hofman, MA; Gooren, LJG; Swaab, DF;
Indirizzi:
Netherlands Inst Brain Res, Grad Sch Neurosci, NL-1105 AZ Amsterdam, Netherlands Netherlands Inst Brain Res Amsterdam Netherlands NL-1105 AZ Netherlands Free Univ Amsterdam Hosp, Dept Endocrinol, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Anhui Univ, Affiliated Hosp 1, Anhui Geriatr Inst, Hefei 230032, Anhui, Peoples R China Anhui Univ Hefei Anhui Peoples R China 230032 032, Anhui, Peoples R China
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 5, volume: 85, anno: 2000,
pagine: 2034 - 2041
SICI:
0021-972X(200005)85:5<2034:MTHFNN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; HUMAN-BRAIN; STRIA TERMINALIS; BED NUCLEUS; SUPRACHIASMATIC NUCLEUS; PERIVENTRICULAR NUCLEUS; SEXUAL-DIFFERENTIATION; SOMATOSTATIN NEURONS; HOMOSEXUAL MEN; MALE-RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kruijver, FPM Netherlands Inst Brain Res, Grad Sch Neurosci, Meibergdreef 33, NL-1105 AZAmsterdam, Netherlands Netherlands Inst Brain Res Meibergdreef 33 Amsterdam Netherlands NL-1105 AZ
Citazione:
F.P.M. Kruijver et al., "Male-to-female transsexuals have female neuron numbers in a limbic nucleus", J CLIN END, 85(5), 2000, pp. 2034-2041

Abstract

Transsexuals experience themselves as being of the opposite sex, despite having the biological characteristics of one sex. A crucial question resulting from a previous brain study in male-to-female transsexuals was whether the reported difference according to gender identity in the central part of the bed nucleus of the stria terminalis (BSTc) was based on a neuronal difference in the BSTc itself or just a reflection of a difference in vasoactive intestinal polypeptide innervation from the amygdala, which was used as amarker. Therefore, we determined in 42 subjects the number of somatostatin-expressing neurons in the BSTc in relation to sex, sexual orientation, gender identity, and past or present hormonal status. Regardless of sexual orientation, men had almost twice as many somatostatin neurons as women (P < 0.006). The number of neurons in the BSTc of male-to-female transsexuals wassimilar to that of the females (P = 0.83). In contrast, the neuron number of a female-to-male transsexual was found to be in the male range. Hormone treatment or sex hormone level variations in adulthood did not seem to haveinfluenced BSTc neuron numbers. The present findings of somatostatin neuronal sex differences in the BSTc and its sex reversal in the transsexual brain clearly support; the paradigm that in transsexuals sexual differentiation of the brain and genitals may go into opposite directions and point to a neurobiological basis of gender identity disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:58:35