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Titolo: Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle
Autore: Kitawaki, J; Koshiba, H; Ishihara, H; Kusuki, I; Tsukamoto, K; Honjo, H;
- Indirizzi:
- Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
- Titolo Testata:
- JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 5,
volume: 85,
anno: 2000,
pagine: 1946 - 1950
- SICI:
- 0021-972X(200005)85:5<1946:EOLRIH>2.0.ZU;2-X
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- REGULATORY PROTEINS; FEMALE MICE; OBESE; CLONING; STAT3; MOUSE; CELLS; ISOFORMS; PLACENTA; OOCYTE;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Life Sciences
- Citazioni:
- 28
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Kitawaki, J Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kamigyo Ku,465 Kajii Cho, Kyoto 6028566, Japan Kyoto Prefectural Univ Med 465 Kajii Cho Kyoto Japan 6028566
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- Citazione:
- J. Kitawaki et al., "Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle", J CLIN END, 85(5), 2000, pp. 1946-1950
Abstract
Leptin is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors (OB-R). Accumulated evidence shows that leptin is involved in the stimulation of reproductive functions and that local expression of leptin and OB-R in the ovary, oocyte, embryo, and placenta plays a role in early development. To investigate the role of leptin inimplantation, we examined the expression of OB-R and leptin in the human endometrium. Northern and Western blot analyses and RT-PCR showed that the long form of OB-R (OB-R,) messenger ribonucleic acid (mRNA) and protein wereexpressed. In contrast, leptin mRNA or protein was not detected. All of the splice variants of OB-R (OB-R,) and OB-R-L transcripts were expressed in 90% and 84% of the cases, respectively. OB-R mRNA expression peaked in the early secretory phase. Decidual tissue of early gestation also expressed OB-R-T and OB-R-L. Their incidence and abundance were comparable among endometria with benign uterine diseases and disease-free endometria and were not related to a body mass index within the normal range. The present results indicate that OB-R, but not leptin, is expressed in the human endometrium.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:55:42