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Titolo:
Thyroid hormone receptor gene expression in first trimester human fetal brain
Autore:
Iskaros, J; Pickard, M; Evans, I; Sinha, A; Hardiman, P; Ekins, R;
Indirizzi:
Univ Coll London, Sch Med, Div Mol Endocrinol, London W1N 8AA, England Univ Coll London London England W1N 8AA ocrinol, London W1N 8AA, England N Middlesex Hosp, Dept Obstet & Gynecol, London N18 1QX, England N Middlesex Hosp London England N18 1QX Gynecol, London N18 1QX, England
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 7, volume: 85, anno: 2000,
pagine: 2620 - 2623
SICI:
0021-972X(200007)85:7<2620:THRGEI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING RAT-BRAIN; PREGNANCY; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sinha, A Univ Coll London, Sch Med, Div Mol Endocrinol, Mortimer St, London W1N 8AA, England Univ Coll London Mortimer St London England W1N 8AA 8AA, England
Citazione:
J. Iskaros et al., "Thyroid hormone receptor gene expression in first trimester human fetal brain", J CLIN END, 85(7), 2000, pp. 2620-2623

Abstract

Maternal thyroid hormone is transferred to the fetus early in pregnancy and is postulated to regulate brain development. Thyroid hormone nuclear receptor (TR) proteins are present in fetal brain, but their isoformal composition is unknown. We therefore investigated the ontogeny of TR isoforms and related splice variants in first trimester human fetal brain (n = 9) by semi-quantitative reverse transcriptase-polymerase chain reaction analysis. Expression of the TR beta 1, TR alpha 1 and c-erbA alpha 2 isoforms was detected from 8.1 weeks gestation (wg). An additional truncated species was detected with the c-erbA alpha 2 primer set, consistent with the c-erb alpha 3 splice variant previously described in the rat. All c-erA alpha-derived transcripts were co-ordinately expressed and increased (ca. 8-fold) between 8.1and 13.9 wg. A more complex ontogenic pattern was observed for TR beta 1, suggestive of a nadir between 8.4 and 12.0 wg. These findings point to an important role for the TR alpha 1 isoform in mediating maternal thyroid hormone action during first trimester human fetal brain development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 13:27:36