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Titolo:
Rupture of pseudointima in an implanted vascular prosthesis: immunohistological study plasminogen activators and matrix metalloproteinases
Autore:
Urayama, H; Katada, S; Kasashima, F; Tanaka, Y; Kawasuji, M; Watanabe, Y;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR SURGERY
fascicolo: 3, volume: 41, anno: 2000,
pagine: 459 - 462
SICI:
0021-9509(200006)41:3<459:ROPIAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; DACRON;
Keywords:
blood vessel prosthesis; tunica intima; postoperative complications; anastomosis, surgical adverse effects; plasminogen activators; metalloproteinases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Urayama, H Kanazawa Univ, Sch Med, Dept Surg 1, 13-1 Takara Machi, Kanazawa, Ishikawa9208641, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa IshikawaJapan 9208641
Citazione:
H. Urayama et al., "Rupture of pseudointima in an implanted vascular prosthesis: immunohistological study plasminogen activators and matrix metalloproteinases", J CARD SURG, 41(3), 2000, pp. 459-462

Abstract

We investigated late-onset anastomotic stenosis in an implanted prostheticgraft. Rupture of the pseudointima and hemorrhaging from the vasa vasorum were observed at the border of the collagenous tissue and fibrin layer. An immunohistological study showed that the fibrin layer was positive for tPA,but weakly positive for PAI-1. Some neutrophils and monocyte/macrophages in the fibrin layer were immunostained for tPA, uPA, uPAR, and MMP-1, -2 and-3. Some spindle-shaped cells surrounding the graft were immunostained foruPA, uPAR, MMP-1, -2, -3, -7 and -9, and TIMP-1 and -2. The endothelial cells of some microvessels mere positive for MMP-1 and -2, and tPA. Some multi-nucleated giant cells were immunostained for MMP-7 and-9, tPA, PAI-1, uPA, and uPAR. Overexpressed MMPs and PAs possibly caused instability of the pseudointima.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 21:40:06