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Titolo:
Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes
Autore:
Lee, CH; Marekov, LN; Kim, SY; Brahim, JS; Park, MH; Steinert, PM;
Indirizzi:
NIAMS, Skin Biol Lab, NIH, Bethesda, MD 20892 USA NIAMS Bethesda MD USA 20892 S, Skin Biol Lab, NIH, Bethesda, MD 20892 USA NIDCR, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA NIDCR Bethesda MD USA 20892 geal Canc Branch, NIH, Bethesda, MD 20892 USA NIDCR, Clin Res Core, NIH, Bethesda, MD 20892 USA NIDCR Bethesda MD USA 20892 R, Clin Res Core, NIH, Bethesda, MD 20892 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 477, anno: 2000,
pagine: 268 - 272
SICI:
0014-5793(20000721)477:3<268:SPP1IT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGLUTAMINASE CROSS-LINKING; STRATIFIED SQUAMOUS EPITHELIA; EPIDERMAL-KERATINOCYTES; DIFFERENTIAL EXPRESSION; FAMILY; LORICRIN; INVOLUCRIN; BARRIER; ENZYME;
Keywords:
oral keratinocyte; barrier function; transglutaminase; cell envelope; small proline-rich protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Steinert, PM NIAMS, Skin Biol Lab, NIH, Bldg 6,Room 425, Bethesda, MD 20892 USA NIAMS Bldg 6,Room 425 Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
C.H. Lee et al., "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes", FEBS LETTER, 477(3), 2000, pp. 268-272

Abstract

Oral keratinocytes of buccal and gingival tissues undergo a terminal differentiation program to form a protective epithelial barrier as non-keratinized or parakeratinized stratified cells, We have examined the protein composition of cell envelopes (CEs) from normal human buccal and gingival tissuesas well as keratinocytes from normal human gingival cells grown in culture. Biochemical and sequencing analyses reveal that the CEs contain 60-70% small proline-rich protein 1a/b (SPR1a/b), together with smaller amounts of involucrin, annexin I and several other known CE proteins. The data imply a specialized role for SPR1 proteins in the unique barrier function requirements of oral epithelia, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:38:35