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Titolo:
Failure of neuroprotection by embryonic striatal grafts in a double lesionrat model of striatonigral degeneration (multiple system atrophy)
Autore:
Puschban, Z; Waldner, R; Seppi, K; Stefanova, N; Humpel, C; Scherfler, C; Levivier, M; Poewe, W; Wenning, GK;
Indirizzi:
Univ Innsbruck Hosp, Dept Neurol, Neurol Res Lab, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Free Univ Brussels, Hop Erasme, Dept Neurosurg, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 urg, B-1070 Brussels, Belgium Med Univ Sofia, Dept Anat & Histol, Sofia 1431, Bulgaria Med Univ Sofia Sofia Bulgaria 1431 t Anat & Histol, Sofia 1431, Bulgaria Univ Innsbruck Hosp, Dept Psychiat, Lab Psychiat, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 164, anno: 2000,
pagine: 166 - 175
SICI:
0014-4886(200007)164:1<166:FONBES>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GANGLIONIC EMINENCE; ACID-INDUCED LESIONS; QUINOLINIC ACID; HUNTINGTONS-DISEASE; BRAIN INJURY; TRANSPLANTATION; SURVIVAL; DOPAMINE; PROTECTS; PARKINSONISM;
Keywords:
multiple system atrophy; striatonigral degeneration; embryonic striatal grafts; neuroprotection; dopamine D1 and D2 receptors; dopamine reuptake sites; glial activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Puschban, Z Univ Innsbruck Hosp, Dept Neurol, Neurol Res Lab, Anichstr 35,A-6020 Innsbruck, Austria Univ Innsbruck Hosp Anichstr 35 Innsbruck Austria A-6020 tria
Citazione:
Z. Puschban et al., "Failure of neuroprotection by embryonic striatal grafts in a double lesionrat model of striatonigral degeneration (multiple system atrophy)", EXP NEUROL, 164(1), 2000, pp. 166-175

Abstract

In the present experiment we studied the ability of embryonic striatal grafts to protect against striatal quinolinic acid (QA)-induced excitotoxicityin a previously established double lesion rat model of striatonigral degeneration (SND), the neuropathological substrate of parkinsonism associated with multiple system atrophy (MSA), Male Wistar rats received under halothane inhalation anesthesia a 6-hydroxydopamine 6-OHDA injection into the left medial forebrain bundle. Four to 5 weeks later apomorphine-induced rotationbehavior was tested. Rats were divided into two treatment groups receivingeither embryonic striatal cell suspensions or sham injections. Apomorphine-induced rotation behavior was retested 2 and 4 weeks after the grafting procedure. Following the rotation test animals of the striatal and sham graftgroup received a stereotaxic injection of 150 nmol QA. Again rotation behavior was assessed 2 and 4 weeks after lesioning, Brains were then processedto dopamine reuptake ([H-3]mazindol), dopamine D1 ([H-3]SCH23390), and D2 ([H-3]spiperone) receptor autoradiography, Gliosis was detected using [H-3]PK11195, a marker for peripheral benzodiazepine binding sites. Behavioral and autoradiographic analysis failed to show striatal protection in 6-OHDA prelesioned animals receiving embryonic striatal grafts, These findings indicate that beneficial protective effects of striatal grafts implanted into host striatum prior to excitotoxic insults are abolished in the presence of severe dopaminergic denervation, Our present results are relevant to futureapplications of neural grafting in MSA-SND. (C) 2000 Academic Press.

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Documento generato il 14/07/20 alle ore 19:42:31