Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
2,3,7,8-tetrachlorodibenzo-p-dioxin alters follicular steroidogenesis in time- and cell-specific manner
Autore:
Pieklo, R; Grochowalski, A; Gregoraszczuk, EL;
Indirizzi:
Jagiellonian Univ, Inst Zool, Dept Anim Physiol, PL-30060 Krakow, Poland Jagiellonian Univ Krakow Poland PL-30060 hysiol, PL-30060 Krakow, Poland Univ Technol, Dept Chem, Krakow, Poland Univ Technol Krakow PolandUniv Technol, Dept Chem, Krakow, Poland
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 4, volume: 108, anno: 2000,
pagine: 299 - 304
SICI:
0947-7349(2000)108:4<299:2AFSIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZED GRANULOSA-CELLS; FEMALE RAT; IN-UTERO; TCDD; MECHANISM; ANTIESTROGENS; PROGESTERONE; SECRETION; ESTROGEN;
Keywords:
TCDD; theca interna; granulosa cells; steroidogenesis; pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Gregoraszczuk, EL Jagiellonian Univ, Inst Zool, Dept Anim Physiol, PL-30060 Krakow, Poland Jagiellonian Univ Krakow Poland PL-30060 rakow, Poland
Citazione:
R. Pieklo et al., "2,3,7,8-tetrachlorodibenzo-p-dioxin alters follicular steroidogenesis in time- and cell-specific manner", EXP CL E D, 108(4), 2000, pp. 299-304

Abstract

To show the direct effect of TCDD on ovarian steroidogenesis theca (Tc) and granulosa (Gc) cells were cultured separately or as a co-culture (GT). Cells were cultured in M199 medium supplemented every day with 0.1 nM TCDD oronly at the beginning of the culture with 10 nM of TCDD. After 48, 96 and 144 h culture media were collected for steroids content analysis. In Tc cultured alone TCDD caused an increase in E2 production after 48 and 96 h of culture: while exposure of Tc on TCDD for 144 h caused the decrease in both T and E2 secretion. In Cc cultured alone and in GT cultures the increase inE2 secretion was observed only after 48 h. while a long term exposure to TCDD (96 and 144 h) caused a decrease of both P4 and E2 secretion. The results of the present study suggest various, time-dependent mechanisms of TCDD action on ovarian cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:54:53