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Titolo:
Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women
Autore:
Bauer, J; Jarre, A; Klingmuller, D; Elger, CE;
Indirizzi:
Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 nn, Dept Epileptol, D-53105 Bonn, Germany Univ Bonn, Dept Clin Biochem, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 n, Dept Clin Biochem, D-5300 Bonn, Germany
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2, volume: 41, anno: 2000,
pagine: 163 - 167
SICI:
0920-1211(200009)41:2<163:POSIPW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; MULTIFOLLICULAR OVARIES; ENDOCRINE DISORDERS; VALPROATE; POPULATION; PREVALENCE; MEDICATION; FERTILITY; HORMONE; COMMON;
Keywords:
epilepsy; polycystic ovary syndrome; anticonvulsant treatment; valproate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, J Univ Bonn, Dept Epileptol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 onn, Germany
Citazione:
J. Bauer et al., "Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women", EPILEPSY R, 41(2), 2000, pp. 163-167

Abstract

A prospective cohort analysis of premenopausal women with focal epilepsy was conducted in order to determine whether polycystic ovary syndrome (PCOS)is a common finding in women treated with antiepileptic drugs (AED). This study was carried out in 93 of 150 women (aged between 20 and 53 years; mean, 34.3 years) with chronic focal epilepsy consecutively cared for at the Department of Epileptology, University of Bonn: 38 were receiving one AED (18 valproate, 20 carbamazepine), 36 more than one drug, and 19 were without medication. Patients were followed-up for 6 months. PCOS was defined as hyperandrogenism (testosterone concentration, > 0.7 ng/ml) combined with oligomenorrhoea (cycle length, >35 days) or amenorrhoea. PCOS was identified in two out of 19 (10.5%) patients receiving no medication; in four of 38 (10.5%) of patients receiving monotherapy, and in none of the patients receivingmore than one AED. The incidence of PCOS in patients treated with valproate monotherapy (11.1%) was similar to that in patients treated with carbamazepine (10%) and also to that in patients not treated with AEDs. The resultsof this study suggest that the manifestation of PCOS in women with focal epilepsy is not related to the administration of valproate or carbamazepine. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:48:53