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Titolo:
Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy
Autore:
Takeda, Y; Yoneda, T; Demura, M; Miyamori, I; Mabuchi, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Hlth Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Fukui Med Sch, Dept Internal Med 3, Fukui 91011, Japan Fukui Med Sch Fukui Japan 91011 Dept Internal Med 3, Fukui 91011, Japan
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 5, volume: 141, anno: 2000,
pagine: 1901 - 1904
SICI:
0013-7227(200005)141:5<1901:SCASCC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENIN-ANGIOTENSIN SYSTEM; LEFT-VENTRICULAR HYPERTROPHY; HYPERTENSIVE RATS; VASCULAR ALDOSTERONE; GENETIC-ANALYSIS; II RECEPTOR; HEART; BIOSYNTHESIS; EXPRESSION; FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Ishikawa 920, Japan
Citazione:
Y. Takeda et al., "Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy", ENDOCRINOL, 141(5), 2000, pp. 1901-1904

Abstract

High sodium intake causes cardiac hypertrophy independently of increases in blood pressure. Aldosterone is synthesized in extraadrenal tissues such as blood vessels, brain, and heart. Effects of 8 weeks of high sodium intakeon cardiac aldosterone synthesis, as well as cardiac structure, mass, and aldosterone production, levels of mRNA coding for aldosterone synthase (CYP11B2) and the angiotensin TI AT 1 receptor, were studied in normotensive Wistar-Kyoto (WKY) rats. Isolated rat hearts were perfused for 2 hr, and the perfusate was analyzed by high-performance liquid chromatography and mass spectrometry. Aldosterone synthase activity was estimated from the conversion of [C-14]deoxycorticosterone to [C-14]aldosterone. Levels of mRNA for CYP11BZ and AT 1 receptor were determined by competitive polymerase chain reactions. A high sodium intake for 8 weeks produced left ventricular hypertrophy without elevation of blood pressure. Plasma aldosterone concentrations and plasma renin concentrations were decreased by high sodium intake. Aldosterone production, activity of aldosterone synthase, and expression of mRNA for CYP11B2 and AT 1 receptor were increased in hearts of rats with high sodium intake. These results suggest that high sodium intake increases cardiac aldosterone synthesis, which may contribute to cardiac hypertrophy independently of the circulating renin-angiotensin-aldosterone system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:27:13