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Titolo:
Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase
Autore:
Hobby, P; Gardas, A; Radomski, R; McGregor, AM; Banga, JP; Sutton, BJ;
Indirizzi:
Univ London Kings Coll, Randall Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England Univ London Kings Coll, Guys Kings & St Thomas Sch Med, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL d, London SE1 1UL, England Warsaw Univ, Sch Med, Med Ctr Postgrad Educ, PL-01813 Warsaw, Poland Warsaw Univ Warsaw Poland PL-01813 ostgrad Educ, PL-01813 Warsaw, Poland Warsaw Univ, Sch Med, Dept Med Informat, PL-01813 Warsaw, Poland Warsaw Univ Warsaw Poland PL-01813 Med Informat, PL-01813 Warsaw, Poland
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 6, volume: 141, anno: 2000,
pagine: 2018 - 2026
SICI:
0013-7227(200006)141:6<2018:IOAIRR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAY CRYSTAL-STRUCTURE; B-CELL EPITOPE; HASHIMOTOS-THYROIDITIS; DISEASE; PROTEIN; MYELOPEROXIDASE; AUTOANTIGEN; ANTIBODIES; DOMAIN; FRAGMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Sutton, BJ Univ London Kings Coll, Randall Ctr, New Hunts House,Guys Campus, London SE1 1UL, England Univ London Kings Coll New Hunts House,Guys Campus London England SE1 1UL
Citazione:
P. Hobby et al., "Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase", ENDOCRINOL, 141(6), 2000, pp. 2018-2026

Abstract

Autoimmune thyroid diseases (AITD) are characterized by the presence of autoantibodies to thyroid peroxidase (TPO). This response is dominated by autoantibodies to two conformational determinants, termed A and B, that have been defined by monoclonal antibodies but whose structures and location within TPO are unknown. We have modeled the three-dimensional structure of the extracellular region of TPO, raised antisera to prominent surface structures, and identified an epitope that we show to be a critical part of the B determinant. Antibodies to this epitope inhibit the binding to TPO of human autoantibodies in virtually all serum samples from 65 patients with AITD that were tested. This first description of a model of the three-dimensional structure and location of a major autoantigenic determinant within the TPO molecule may provide structural clues for identifying causative agents or developing novel therapeutic strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:24:10