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Titolo:
Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: Possible role for ceramide
Autore:
Chae, HJ; Chae, SW; Kang, JS; Bang, BG; Cho, SB; Park, RK; So, HS; Kim, YK; Kim, HM; Kim, HR;
Indirizzi:
Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Wonkwang Univ, Sch Dent, Wonkwang Dent Res Inst, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Med, Dept Microbiol & Immunol, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Chonbuk Natl Univ, Sch Med, Cardiovasc Res Inst, Chonbuk 570749, South Korea Chonbuk Natl Univ Chonbuk South Korea 570749 Chonbuk 570749, South Korea Chonbuk Natl Univ, Sch Med, Dept Pharmacol, Chonbuk 570749, South Korea Chonbuk Natl Univ Chonbuk South Korea 570749 Chonbuk 570749, South Korea
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 8, volume: 141, anno: 2000,
pagine: 2904 - 2913
SICI:
0013-7227(200008)141:8<2904:DSTNFA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; CELL-DEATH; SIGNAL-TRANSDUCTION; MEDIATED APOPTOSIS; GENE-EXPRESSION; CYTOCHROME-C; GLUCOCORTICOIDS; MODULATION; BCL-2; THAPSIGARGIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HR Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 honbuk, SouthKorea
Citazione:
H.J. Chae et al., "Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: Possible role for ceramide", ENDOCRINOL, 141(8), 2000, pp. 2904-2913

Abstract

Ceramide has been proposed as a second messenger molecule implicated in a variety of biological processes, including apoptosis. Recently, it has beenreported that tumor necrosis factor-alpha (TNF-alpha) activates the release of ceramide and that ceramide acts as a mediator for the TNF-alpha-induced stimulation of the binding affinity of nuclear factor-kappa B (NF-kappa B), a ubiquitous transcription factor of particular importance in immune andinflammatory responses. In this study we demonstrate that dexamethasone, which reduces the production of ceramide, significantly inhibits TNF-alpha-induced activation of NF-kappa B, c-Jun N-terminal kinase, also known as stress-activating protein kinase, caspase-8-like cysteine protease, redistribution of cytochrome c, and apoptosis in MC3T3E1 osteoblasts. Compared with TNF-alpha-induced JNK activation, ceramide elicits a more rapid activation of JNK within 30 min. C-2-ceramide activates NF-kappa B and caspase-3 like protease to the same degree and with kinetics similar to those of TNF-alpha. This study provides evidence that the release of ceramide may be required as a second messenger in TNF-alpha-induced apoptosis. These results also suggest a regulatory role for dexamethasone in TNF-alpha-induced apoptosis via inhibition of ceramide release. Therefore, our in, vitro results suggest that therapies targeted at the inhibition of ceramide release may abrogate inflammatory processes in TNF-alpha-related diseases, including rheumatoid arthritis and periodontitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:17:45