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Titolo:
Pulmonary surfactant is altered during mechanical ventilation of isolated rat lung
Autore:
Veldhuizen, RAW; Tremblay, LN; Govindarajan, A; van Rozendaal, BAWM; Haagsman, HP; Slutsky, AS;
Indirizzi:
Univ Western Ontario, Lawson Res Inst, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, Dept Med, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, Dept Physiol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Toronto, Mt Sinai Hosp, Dept Med, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 t Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Mt Sinai Hosp, Dept Surg, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Surg, Toronto, ON M5G 1X5, Canada Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Utrecht, Fac Med Vet, Vet Biochem Lab, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands Univ Utrecht, Fac Med Vet, Grad Sch Anim Hlth, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 7, volume: 28, anno: 2000,
pagine: 2545 - 2551
SICI:
0090-3493(200007)28:7<2545:PSIADM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; AGGREGATE CONVERSION; CHEMICAL-COMPOSITION; IN-VITRO; INJURY; EDEMA; SUBFRACTIONS; PRESSURES; PROTEINS; ACID;
Keywords:
surfactant; mechanical ventilation; lung lavage; tumor necrosis factor-alpha; SP-A; SP-D; surfactant aggregates; ventilator induced lung injury; positive end-expiratory pressure; lung injury; acute respiratory distress syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Veldhuizen, RAW Univ Western Ontario, Lawson Res Inst, Room G454,268 Grosvenor St, London,ON N6A 4V2, Canada Univ Western Ontario Room G454,268 Grosvenor St London ON Canada N6A 4V2
Citazione:
R.A.W. Veldhuizen et al., "Pulmonary surfactant is altered during mechanical ventilation of isolated rat lung", CRIT CARE M, 28(7), 2000, pp. 2545-2551

Abstract

Objective: To test the hypothesis that the lung injury induced by certain mechanical ventilation strategies is associated with changes in the pulmonary surfactant system. Design: Analysis of the pulmonary surfactant system from isolated rat lungs after one of four different ventilatory strategies. Setting: A research laboratory at a university. Subjects: A total of 45 Sprague-Dawley rats. Interventions: Isolated lungs were randomized to either no ventilation (0-TIME) or to ventilation at 40 breaths/min in a humidified 37 degrees C chamber for either 30 mins or 120 mins with one of the following four strategies: a) control (CON, 7 mL/kg, 3 cm H2O positive end-expiratory pressure); b)medium volume, zero end-expiratory pressure (MVZP, 15 mL/kg, 0 cm H2O end-expiratory pressure); c) medium volume, high positive end-expiratory pressure (MVHP, 15 mL/kg, 9 cm H2O positive end-expiratory pressure); and d) highvolume, zero end-expiratory pressure (HVZP, 40 mL/kg, 0 cm H2O end-expiratory pressure). Measurements: Pressure-volume curves were determined before and after the ventilation period, after which the lungs were lavaged for surfactant analysis. Main Results: Compared with 0-TIME, 30 mins of ventilation with the HVZP strategy or 120 mins of ventilation with CON and MVZP strategies caused a significant decrease in compliance. Groups showing a decreased compliance hadsignificant increases in the amount of surfactant, surfactant large aggregates, and total lavage protein compared with 0-TIME. Conclusions: A short period of injurious mechanical ventilation can cause a decrease in lung compliance that is associated with a large influx of proteins into the alveolar space and with alterations of the pulmonary surfactant system. The changes of surfactant in these experiments are different from those seen in acute lung injury, indicating that they may represent an initial response to mechanical ventilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:18:43