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Titolo:
Endotracheal surfactant atomization: An alternative to bolus instillation?
Autore:
Wagner, MH; Amthauer, H; Sonntag, J; Drenk, F; Eichstadt, HW; Obladen, M;
Indirizzi:
Humboldt Univ, Dept Neonatol, Berlin, Germany Humboldt Univ Berlin Germany boldt Univ, Dept Neonatol, Berlin, Germany Humboldt Univ, Dept Radiol, Charite, Berlin, Germany Humboldt Univ Berlin Germany niv, Dept Radiol, Charite, Berlin, Germany Fraunhofer Inst Toxicol & Aerosol Res, D-3000 Hannover, Germany FraunhoferInst Toxicol & Aerosol Res Hannover Germany D-3000 r, Germany
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 7, volume: 28, anno: 2000,
pagine: 2540 - 2544
SICI:
0090-3493(200007)28:7<2540:ESAAAT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; CEREBRAL BLOOD-FLOW; LUNG-LAVAGED RABBITS; AEROSOLIZED SURFACTANT; EXOGENOUS SURFACTANT; REPLACEMENT THERAPY; PORCINE SURFACTANT; PRETERM LAMBS; NEBULIZATION; MODEL;
Keywords:
adult respiratory distress syndrome; surfactant therapy; instillation method; bolus instillation; surfactant atomization; surfactant fog; droplet size; oxygenation; recovery rate; surfactant distribution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Wagner, MH Humboldt Univ, Dept Neonatol, Campus Virchow Hosp, Berlin, Germany Humboldt Univ Campus Virchow Hosp Berlin Germany lin, Germany
Citazione:
M.H. Wagner et al., "Endotracheal surfactant atomization: An alternative to bolus instillation?", CRIT CARE M, 28(7), 2000, pp. 2540-2544

Abstract

Objective: To investigate the effect of an intratracheal surfactant fog onoxygenation, blood pressure, distribution, and recovery rate as a pilot study to intratracheal surfactant aerosol. Design: Prospective, randomized study. Setting: University laboratory. Subjects: A total of 15 New Zealand White rabbits. Interventions: The anesthetized ventilated rabbits were surfactant-deprived by repeated lung lavages and then received 200 mg/kg of a Tc-99m-labeled porcine surfactant (Curosurf) either as bolus or as intratracheal surfactant fog. Measurements and Main Results: Blood gases and pressure were measured and distribution as well as recovery rate of the surfactant determined by meansof the radio label (gamma camera images and lung processing with subsequent gamma counter measurements). Respiratory function normalized immediately, no difference could be found between the two groups with regard to pao Paco(2), and blood pressure. Evendistribution of the radiolabel was found with both methods, the bolus group showing a higher percentage of lung pieces with label concentrations of double average or more. Recovery rates were 82.5% +/- 13.1% (mean +/- SD) inthe bolus group and 86.5% +/- 7.7% in the fog group. Conclusion: Endotracheal surfactant fog application is as effective as bolus instillation and may have a role in the treatment of adult respiratory distress syndrome. It has to be considered as a first step in producing an effective aerosol.

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Documento generato il 06/04/20 alle ore 19:03:10