Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of norepinephrine on the distribution of intestinal blood flow andtissue adenosine triphosphate content in endotoxic shock
Autore:
Revelly, JP; Liaudet, L; Frascarolo, P; Joseph, JM; Martinet, O; Markert, M;
Indirizzi:
Univ Lausanne Hosp, CHUV, Surg Intens Care Unit, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne Hosp, CHUV, Dept Anesthesiol, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne Hosp, CHUV, Dept Internal Med, CH-1011 Lausanne, SwitzerlandUniv Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne Hosp, CHUV, Med Intens Care Unit, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne Hosp, CHUV, Dept Surg, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne Hosp, CHUV, Cent Lab Clin Chem, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 7, volume: 28, anno: 2000,
pagine: 2500 - 2506
SICI:
0090-3493(200007)28:7<2500:EONOTD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEPTIC SHOCK; OXYGEN EXTRACTION; ENERGY-METABOLISM; SEPSIS; PERFUSION; PIGS; HETEROGENEITY; HYPOPERFUSION; VASOPRESSORS; EPINEPHRINE;
Keywords:
animal model; colored microspheres; endotoxin; sepsis; splanchnic perfusion; swine; intestinal muscularis; intestinal mucosa; tonometric pH; oxygen consumption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Revelly, JP Univ Lausanne Hosp, CHUV, Surg Intens Care Unit, Room 08-660, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Room 08-660 Lausanne Switzerland CH-1011 d
Citazione:
J.P. Revelly et al., "Effects of norepinephrine on the distribution of intestinal blood flow andtissue adenosine triphosphate content in endotoxic shock", CRIT CARE M, 28(7), 2000, pp. 2500-2506

Abstract

Objective: To investigate, during endotoxic shock, the effect of a treatment of norepinephrine (NE) administration on the distribution of blood flow and adenosine triphosphate (ATP) content in the intestinal wall. Design: Randomized controlled trial. Setting: Animal laboratory. Subjects: Domestic pigs. Intervention: A total of 18 pigs were anesthetized with ketamine and pentobarbital, mechanically ventilated, hemodynamically monitored, and then challenged with a continuous infusion of Escherichia coli endotoxin (ET) (15 mug/kg) for 2 hrs. Three groups of six animals were studied; one served as time control, one group received ET and fluid resuscitation, and a third group received ET, fluid resuscitation, and a perfusion of NE to maintain constant mean arterial pressure (MAP). Measurements and Main Results: Cardiac output, mesenteric arterial blood flow, MAP, pulmonary pressure, and portal pressure were measured. Intestinalmucosal intracellular pH (pHi) was determined with saline-filled balloon tonometers. Tissue blood flows to the intestinal mucosa and to the muscular layer were independently measured with fluorescent microspheres, using the arterial reference sample method. Measurements were performed before and 3 hrs after the start of the ET challenge. At the end of the experiments, muscularis and mucosal samples were quickly frozen for further enzymatic ATP measurements. ET administration with fluid resuscitation induced a distributive shock with increased mucosal blood flow and decreased muscularis blood flow, whereas pHi decreased and mucosal ATP content was significantly lower than in the control group. In the group receiving ET plus NE, MAP remained constant, mucosal blood flow didnot increase, and mucosal ATP content was equal to the time control group. Meanwhile, mucosal acidosis was not prevented. Conclusions: Normodynamic endotoxic shock may induce an alteration in mucosal oxygenation, despite an increased tissue blood flow. A treatment of NE combined with fluid resuscitation has complex effects on tissue blood flow,ATP content, and pHi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:26:25