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Titolo:
Sarcoplasmic reticulum Ca2+-ATPase of sea cucumber smooth muscle: regulation by K+ and ATP
Autore:
Landeira-Fernandez, AM; Galina, A; Jennings, P; Montero-Lomeli, M; de Meis, L;
Indirizzi:
Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Bioquim Med, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21941590 BCeiro, Brazil
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 2, volume: 126, anno: 2000,
pagine: 263 - 274
SICI:
1095-6433(200006)126:2<263:SRCOSC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+ TRANSPORT ATPASES; SKELETAL-MUSCLE; FLUORESCEIN ISOTHIOCYANATE; ADENOSINE-TRIPHOSPHATASE; CALCIUM-TRANSPORT; MOLECULAR-CLONING; BLOOD-PLATELETS; BINDING SITES; CA-2+ PUMP; ISOFORMS;
Keywords:
SERCA-ATPase; smooth muscle; K+-dependence; Ca2+-transport; sea cucumber; uncoupling by ATP; bioenergetics; marine invertebrates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: de Meis, L Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Bioquim Med, Cidade Univ, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Cidade Univ Rio De Janeiro Brazil BR-21941590 BC
Citazione:
A.M. Landeira-Fernandez et al., "Sarcoplasmic reticulum Ca2+-ATPase of sea cucumber smooth muscle: regulation by K+ and ATP", COMP BIOC A, 126(2), 2000, pp. 263-274

Abstract

Although several Ca2+-ATPase isoforms have been described in vertebrates, little is known about Ca2+-transport in the muscle of invertebrates. In themicrosomal fraction obtained from the sea cucumber (Ludwigothurea grisea) longitudinal body wall smooth muscle, we identified a Ca2+-transport ATPasethat is able to transport Ca2+ at the expense of ATP hydrolysis. This enzyme has a high affinity for both. Ca2+ and ATP, an optimum pH around 7.0, and - different from the vertebrate sarcoplasmic reticulum Ca2+-ATPases isoforms so far described - is activated 3- to 5-fold by K+ but not by Li+, at all temperatures, Ca2+ and ATP concentrations tested. Calcium accumulation by the sea cucumber microsomes is inhibited by Mg/ATP concentrations > 1 mM and the accumulated Ca2+ is released to the medium when the ATP concentration is raised from 0.1 to 4.0 mM. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:02:33