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Titolo:
Gastrin secretion by ovine antral mucosa in vitro
Autore:
Lawton, DEB; Simcock, DC; Candy, EJ; Simpson, HV;
Indirizzi:
Massey Univ, Coll Sci, Inst Food Nutr & Human Hlth, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand Palmerston North, New Zealand
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 2, volume: 126, anno: 2000,
pagine: 233 - 243
SICI:
1095-6433(200006)126:2<233:GSBOAM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT STOMACH; VASOACTIVE INTESTINAL POLYPEPTIDE; GENE-RELATED PEPTIDE; ACID-SECRETION; SOMATOSTATIN SECRETION; MONOCLONAL-ANTIBODY; ENDOCRINE-CELLS; CHOLINERGIC NEURONS; VAGAL-STIMULATION; DUODENAL-ULCER;
Keywords:
carbachol; gastrin; GIP; GRP; in vitro; somatostatin; sheep; VIP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, HV Massey Univ, Coll Sci, Inst Food Nutr & Human Hlth, Private Bag 11-222, Palmerston North, New Zealand Massey Univ Private Bag 11-222 Palmerston North New Zealand
Citazione:
D.E.B. Lawton et al., "Gastrin secretion by ovine antral mucosa in vitro", COMP BIOC A, 126(2), 2000, pp. 233-243

Abstract

The effect on gastrin and somatostatin release in sheep of stimulatory andinhibitory peptides and pharmacological agents was investigated using an in vitro preparation of ovine antral mucosa. Carbachol stimulated gastrin release in a dose-dependent manner but had no effect on somatostatin release. As atropine blocked the effect of carbachol, cholinergic agonists appear to stimulate gastrin secretion directly through muscarinic receptors on the G-cell and not by inhibition of somatostatin secretion. Both vasoactive-intestinal peptide (VIP) and gastric-inhibitory peptide (GIP) increased somatostatin release but did not inhibit basal gastrin secretion, although VIP was effective in reducing the gastrin response to Gastrin-releasing peptide (GRP). Porcine and human GRP were stimulatory to gastrin secretion in high doses but bombesin was without effect. The relative insensitivity to GRP (not of ovine origin) previously reported from intact sheep may be caused either by a high basal release of somatostatin or by the ovine GRP receptor or peptide differing from those of other mammalian species. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:13:16