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Titolo:
Effects of startle and laughter in cataplectic subjects: a neurophysiological study between attacks
Autore:
Lammers, GJ; Overeem, S; Tijssen, MAJ; van Dijk, JG;
Indirizzi:
Leiden Univ, Med Ctr, Dept Neurol & Clin Neurophysiol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 7, volume: 111, anno: 2000,
pagine: 1276 - 1281
SICI:
1388-2457(200007)111:7<1276:EOSALI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-REFLEX; NARCOLEPSY; HYPEREKPLEXIA; EMOTION;
Keywords:
narcolepsy; cataplexy; laughter; startle reflex; H-reflex; audiospinal reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lammers, GJ Leiden Univ, Med Ctr, Dept Neurol & Clin Neurophysiol, POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ POB 9600 Leiden Netherlands NL-2300 RC etherlands
Citazione:
G.J. Lammers et al., "Effects of startle and laughter in cataplectic subjects: a neurophysiological study between attacks", CLIN NEU, 111(7), 2000, pp. 1276-1281

Abstract

Objectives: Cataplexy, when unequivocally present together with excessive daytime sleepiness, is diagnostic for narcolepsy. Unfortunately, it is difficult to induce cataplexy during consultation. In this study we tried to assess presumed subclinical expressions of cataplexy using neurophysiologicaltests. Methods: In this controlled explorative study, we studied 14 patients witha clear history of cataplexy and 12 matched controls using standard H-reflex, H/M ratios, audiospinal reflex, H-reflexes modulated by emotions and startle reflexes. Results: H-reflexes were attenuated during laughter in patients as well ascontrols. Startle reflexes were increased in patients. Audiospinal reflexes were not influenced. Conclusions: The patterns found add relevant knowledge concerning pathophysiological mechanisms and involved brain areas in cataplexy, and may reflect subclinical expressions of cataplexy. The presumed specificity of the abolishment of H-reflexes during cataplectic attacks is questioned by our findings. The exaggerated startle reflex is in line with recent findings concerning involved brain areas in narcolepsy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:15:07