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Titolo:
Vitamin A status in relation to electroretinographic and electrooculographic findings in HIV infection
Autore:
Bartel, P; Roux, P; van Niekerk, M;
Indirizzi:
Pretoria Acad Hosp, Dept Neurol, ZA-0001 Pretoria, South Africa Pretoria Acad Hosp Pretoria South Africa ZA-0001 Pretoria, South Africa Univ Pretoria, ZA-0002 Pretoria, South Africa Univ Pretoria Pretoria South Africa ZA-0002 -0002 Pretoria, South Africa Pretoria Acad Hosp, Dept Ophthalmol, Pretoria, South Africa Pretoria Acad Hosp Pretoria South Africa halmol, Pretoria, South Africa
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 7, volume: 111, anno: 2000,
pagine: 1234 - 1240
SICI:
1388-2457(200007)111:7<1234:VASIRT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
A-DEFICIENCY; CYTOMEGALOVIRUS RETINITIS; RETINOPATHY; POTENTIALS; STANDARD;
Keywords:
HIV; electroretinogram; electrooculogram; vitamin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bartel, P Pretoria Acad Hosp, Dept Neurol, Private Bag X169, ZA-0001 Pretoria, SouthAfrica Pretoria Acad Hosp Private Bag X169 Pretoria South AfricaZA-0001
Citazione:
P. Bartel et al., "Vitamin A status in relation to electroretinographic and electrooculographic findings in HIV infection", CLIN NEU, 111(7), 2000, pp. 1234-1240

Abstract

Objectives: To investigate the electrooculogram (EOG) and an expanded battery of electroretinograms (ERGs) in HIV-infected subjects without retinopathy at two different levels of immunosuppression. Consideration was given tothe possible effects of serum levels of vitamin A. Methods: Two groups of neurologically normal HIV-positive subjects with CD4 + cell counts of <200 (n = 17) or >400 (n = 19) were contrasted with 20 HIV-negative controls. Rod ERGs, oscillatory potentials and cone ERGs were obtained using ganzfeld stimulation. A sequence of dark- and light-adapted EOG recordings was analyzed to obtain light/dark ratios. The HIV-positive subjects underwent a comprehensive ophthalmologic examination. Results: Intergroup comparisons failed to reveal any significant intergroup differences. Abnormal ERG findings, those exceeding the 98% confidence limits, occurred in 11% (4/36) of the HPV-positive subjects. One of these subjects was hyporetinemic and another had a subnormal retinol level. No subjects had abnormal EOGs. Conclusions: HIV infection influenced retinal function in 11% of a group of neurologically normal subjects without clinical signs of retinopathy. Theprofile of electrophysiological findings suggested predominant functional deficits involving middle or inner retinal layers. Vitamin A deficiency andpossible vascular changes could account for the observed ERG abnormalities. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:33:38