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Titolo:
Recovery from methamphetamine induced long-term nigrostriatal dopaminergicdeficits without substantia nigra cell loss
Autore:
Harvey, DC; Lacan, G; Tanious, SP; Melega, WP;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA90095 USA Univ Calif Los Angeles, Sch Med, Brain Res Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 871, anno: 2000,
pagine: 259 - 270
SICI:
0006-8993(20000721)871:2<259:RFMILN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; VESICULAR MONOAMINE TRANSPORTER; SEROTONERGIC AXON TERMINALS; BRAIN TRANSFER CONSTANTS; TIME UPTAKE DATA; STRIATAL DOPAMINE; INDUCED NEUROTOXICITY; C-11 WIN-35,428; RAT-BRAIN; METHYLENEDIOXYMETHAMPHETAMINE MDMA;
Keywords:
methamphetamine; neurotoxicity; neurodegeneration; PET; neuronal plasticity; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Melega, WP Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, 23-120 CHS,Box 951735, Los Angeles, CA 90095 USA Univ Calif Los Angeles 23-120 CHS,Box 951735 Los Angeles CA USA 90095
Citazione:
D.C. Harvey et al., "Recovery from methamphetamine induced long-term nigrostriatal dopaminergicdeficits without substantia nigra cell loss", BRAIN RES, 871(2), 2000, pp. 259-270

Abstract

After administration of methamphetamine (METH) (2x2: mg/kg, 6 h apart) to vervet monkeys, long term but reversible dopaminergic deficits were observed in both in vivo and post-mortem studies. Longitudinal studies using positron emission tomography (PET) with the dopamine transporter (DAT)-binding ligand, [C-11]WIN 35,428 (WIN), were used to show decreases in striatal WIN binding of 80% at 1 week and only 10% at 1.5 years. A post-mortem characterization of other METH subjects at 1 month showed extensive decreases in immunoreactivity (IR) profiles of tyrosine hydroxylase (TH), DAT and vesicularmonoamine transporter-2 (VMAT) in the striatum, medial forebrain bundle and the ventral midbrain dopamine (VMD) cell region. These IR deficits were not associated with a loss of VMD cell number when assessed at 1.5 years by stereological methods. Further, at 1.5],ears, IR profiles of METH subjects throughout the nigrostriatal dopamine system appeared similar to controls although some regional deficits persisted. Collectively, the magnitude and extent of the dopaminergic deficits, and the subsequent recovery were not suggestive of extensive axonal degeneration followed by regeneration. Alternatively, this apparent reversibility of the METH-induced neuroadaptations may be related primarily to long-term decreases in expression of VMD-related proteins that recover over time. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 19:17:10