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Titolo:
Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat
Autore:
Yamamoto, T; Ohtori, S; Chiba, T;
Indirizzi:
Chiba Univ, Sch Med, Dept Anesthesiol, Chiba 260, Japan Chiba Univ ChibaJapan 260 , Sch Med, Dept Anesthesiol, Chiba 260, Japan Chiba Univ, Sch Med, Dept Anat 3, Chiba 260, Japan Chiba Univ Chiba Japan 260 Univ, Sch Med, Dept Anat 3, Chiba 260, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 871, anno: 2000,
pagine: 192 - 200
SICI:
0006-8993(20000721)871:2<192:EOPANO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE CONSTRICTION INJURY; RECEPTOR-LIKE(1) RECEPTOR-AGONIST; AMINO-ACID ANTAGONISTS; SCIATIC-NERVE; SPINAL-CORD; NEUROPATHIC PAIN; DORSAL HORN; PERIPHERAL MONONEUROPATHY; ORPHANIN FQ/NOCICEPTIN; ORL(1) RECEPTOR;
Keywords:
neuropathic pain; ORL1 receptor; nociceptin; spinal cord; pre-emptive analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, T Chiba Univ, Sch Med, Dept Anesthesiol, 1-8-1 Inohana, Chiba 260, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 260 na, Chiba 260, Japan
Citazione:
T. Yamamoto et al., "Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat", BRAIN RES, 871(2), 2000, pp. 192-200

Abstract

Pre-emptive analgesia is thought to be produced by the prevention of spinal facilitation evoked by nociceptive input to the spinal cord. Opioid receptor-like 1 (ORL1) receptor agonist has been reported to inhibit the development of spinal facilitation. We investigated the effect of nociceptin, an ORL1 receptor agonist, on the development of thermal hyperalgesia and the expression of Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn induced by two neuropathic pain models, the chronic constriction injury modeland the partial sciatic nerve injury model. Chronic constriction injury iscreated by placing four loosely tied ligatures around the right sciatic nerve. Partial sciatic nerve injury was created by tight ligation of one third to one half of the right sciatic nerve. All drugs were injected intrathecally 10 min before the nerve injury. The anti-hyperalgesic effect of drugs was evaluated by the measurement of the paw withdrawal latency (PWL) against thermal nociceptive stimulation. The PWLs of the injured paws were measured 7, 14 and 21 days after the nerve injury. Expression of Fos-LI was examined 2 h after the nerve injury. Intrathecal injection of nociceptin significantly delayed the development of thermal hyperalgesia and decreased the expression of Fos-LI induced by chronic constriction injury, but not that induced by partial sciatic nerve injury. These data indicate that pre-emptive administration of nociceptin might be one strategy for the prevention of the development of neuropathic pain. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 07/04/20 alle ore 20:57:52