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Titolo:
Levels of mRNAs encoding synaptic vesicle and synaptic plasma membrane proteins in the temporal cortex of elderly schizophrenic patients
Autore:
Sokolov, BP; Tcherepanov, AA; Haroutunian, V; Davis, KL;
Indirizzi:
NIDA, Mol Neurobiol Branch, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 eurobiol Branch, NIH, Baltimore, MD 21224 USA Mt Sinai Sch Med, Dept Psychiat, New York, NY USA Mt Sinai Sch Med New York NY USA ch Med, Dept Psychiat, New York, NY USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 48, anno: 2000,
pagine: 184 - 196
SICI:
0006-3223(20000801)48:3<184:LOMESV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTOSOMAL-ASSOCIATED PROTEIN; MESSENGER-RNAS; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; SEQUENCE-ANALYSIS; PLANUM TEMPORALE; RT-PCR; EXPRESSION; ABNORMALITIES; SYNAPTOPHYSIN;
Keywords:
Schizophrenia; temporal cortex; synaptic proteins; gene expression; synaptic organization; mRNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Sokolov, BP NIDA, Mol Neurobiol Branch, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 , MD 21224USA
Citazione:
B.P. Sokolov et al., "Levels of mRNAs encoding synaptic vesicle and synaptic plasma membrane proteins in the temporal cortex of elderly schizophrenic patients", BIOL PSYCHI, 48(3), 2000, pp. 184-196

Abstract

Background: Electron microscopy and biochemical studies indicate that developmental abnormalities in synaptic organization may be present in brains of schizophrenic patients. This study determined whether these synaptic abnormalities are reflected in differential or uniform alterations in the expression of various synaptic protein genes in the left superior temporal gyrusof schizophrenic patients. Methods: Levels of nRNAs encoding four synaptic vesicle proteins (synaptotagmin 1 [p65], rab3a, synaptobrevin 1, and synaptobrevin 2) and two synaptic plasma membrane proteins (syntaxin 1A and SNAP-25) were measured post-mortem in the left superior temporal gyrus from elderly (58-95 years) schizophrenic patients (n = 14) and age-matched control subjects (n = 9). Results: There were significant negative correlations between age and levels of synaptotagmin 1 (p65), rab3a, synaptobrevin 1, SNAP-25 and syntaxin 1A mRNAs in schizophrenic patients (-.692 < r < -.517, .003 < p < .030) but not in control subjects. Levels of all six synaptic mRNAs studied were increased in the younger (58-79 years) subgroup of schizophrenic patients compared to control subjects and older (80-95 years) subgroup of schizophrenic patients. Conclusions: That similar abnormalities were found for mRNAs encoding different synaptic vesicle and synaptic plasma membrane proteins suggests that they reflect overall neurodevelopmental abnormalities in synaptic connectivity in the temporal cortex of schizophrenic patients rather than changes inthe number of synaptic vesicles per synapse or abnormalities in a specificsynaptic function. Biol Psychiatry 2000;48:184-196 (C) 2000 Society of Biological Psychiatry.

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Documento generato il 28/01/20 alle ore 21:36:08