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Titolo:
Prohormone transport through the secretory pathway of neuroendocrine cells
Autore:
Kuiper, RP; Martens, GJM;
Indirizzi:
Univ Nijmegen, Dept Anim Physiol, NL-6525 ED Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6525 ED 5 ED Nijmegen, Netherlands
Titolo Testata:
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
fascicolo: 3, volume: 78, anno: 2000,
pagine: 289 - 298
SICI:
0829-8211(2000)78:3<289:PTTTSP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
B SECRETOGRANIN-I; XENOPUS INTERMEDIATE PITUITARY; BIOSYNTHETIC PROTEIN-TRANSPORT; COPII-COATED VESICLES; DISULFIDE-BONDED LOOP; PANCREATIC BETA-CELLS; TO-GOLGI TRANSPORT; ENDOPLASMIC-RETICULUM; CHROMOGRANIN-B; INTRACELLULAR-TRANSPORT;
Keywords:
regulated secretory pathway; p24 family; vesicular transport; POMC; protein sorting; secretory granule; Xenopus laevis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Martens, GJM Univ Nijmegen, Dept Anim Physiol, NL-6525 ED Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6525 ED , Netherlands
Citazione:
R.P. Kuiper e G.J.M. Martens, "Prohormone transport through the secretory pathway of neuroendocrine cells", BIOC CELL B, 78(3), 2000, pp. 289-298

Abstract

En route through the secretory pathway of neuroendocrine cells, prohormones pass a series of membrane-bounded compartments. During this transport, the prohormones are sorted to secretory granules and proteolytically cleaved to bioactive peptides. Recently, progress has been made in a number of aspects concerning secretory protein transport and sorting, particularly with respect to transport events in the early regions of the secretory pathway. In this review we will deal with some of these aspects, including: i) selective exit from the endoplasmic reticulum via COPII-coated vesicles and the potential role of p24 putative cargo receptors in this process, ii) cisternal maturation as an alternative model for protein transport through the Golgi complex, and iii) the mechanisms that may be involved in the sorting of regulated secretory proteins to secretory granules. Although much remains tobe learned, interesting new insights into the functioning of the secretorypathway have been obtained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:16:33