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Titolo:
Interobserver variation in diagnosing coeliac disease. A joint study by Danish and Swedish pathologists
Autore:
Weile, B; Hansen, BF; Hagerstrand, I; Hansen, JPH; Krasilnikoff, PA;
Indirizzi:
Univ Copenhagen, Gentofte Hosp, Dept Paediat, Hellerup, Denmark Univ Copenhagen Hellerup Denmark Hosp, Dept Paediat, Hellerup, Denmark Univ Copenhagen, Hvidovre Hosp, Dept Pathol, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 thol, DK-2650 Hvidovre, Denmark Univ Umea Hosp, Dept Pathol, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185 sp, Dept Pathol, S-90185 Umea, Sweden Univ Copenhagen, Gentofte Hosp, Dept Pathol, Hellerup, Denmark Univ Copenhagen Hellerup Denmark e Hosp, Dept Pathol, Hellerup, Denmark Univ Copenhagen, Hvidovre Hosp, Dept Paediat, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 diat, DK-2650 Hvidovre, Denmark
Titolo Testata:
APMIS
fascicolo: 5, volume: 108, anno: 2000,
pagine: 380 - 384
SICI:
0903-4641(200005)108:5<380:IVIDCD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; INCREASING INCIDENCE; SWEDEN;
Keywords:
coeliac disease; small intestinal biopsy; interobserver variation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Weile, B Statens Serum Inst, Dept Autoimmun, DK-2300 Copenhagen S, DenmarkStatens Serum Inst Copenhagen Denmark S 0 Copenhagen S, Denmark
Citazione:
B. Weile et al., "Interobserver variation in diagnosing coeliac disease. A joint study by Danish and Swedish pathologists", APMIS, 108(5), 2000, pp. 380-384

Abstract

There is an almost 40-fold difference in incidence rates of symptomatic coeliac disease between Denmark and Sweden. In an attempt to explain this difference, the present study focused on the interobserver agreement when pathologists were assessing small intestinal biopsy specimens from children suspected of suffering from coeliac disease. The study was performed on 90 biopsy specimens from 73 children. Most of the biopsies came from children whoturned out not to suffer from coeliac disease after a clinical evaluation including small intestinal biopsy. Using the kappa methodology, the interobserver agreement between two Danish pathologists and one Swedish pathologist, all of whom were experienced, was "moderate" to "substantial" or 0.57-0.75. Kappa indices when the pathologists evaluated selected histological elements were in the interval from 0.24 to 0.67. A comparison of a previous routine diagnostic assessment of the 90 biopsies (14 pathologists) with the results of the experienced pathologists in the present study gave kappa indices of from 0.53 to 0.57. The study could prove no major differences in thehistopathological assessment of small intestinal biopsy specimens made by Danish and Swedish pathologists. The difference in clinical presentation ofcoeliac disease in Denmark and Sweden does not relate to differences in the histopathological assessment of small intestinal biopsies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:22:14