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Titolo:
Power comparison of parametric and nonparametric linkage tests in small pedigrees
Autore:
Sham, PC; Lin, MW; Zhao, JH; Curtis, D;
Indirizzi:
Inst Psychiat, Dept Psychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Psychiat, London SE5 8AF, England Inst Psychiat, Dept Biostat & Comp, London SE5 8AF, England Inst PsychiatLondon England SE5 8AF tat & Comp, London SE5 8AF, England Royal London Hosp, Dept Adult Psychiat, London E1 1BB, England Royal London Hosp London England E1 1BB Psychiat, London E1 1BB, England
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 66, anno: 2000,
pagine: 1661 - 1668
SICI:
0002-9297(200005)66:5<1661:PCOPAN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOD SCORE ANALYSIS; INFERRING MODE; INHERITANCE; SIMULATION; PENETRANCE; LOCI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sham, PC Inst Psychiat, Dept Psychiat, De Crespigny Pk,Denmark Hill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF
Citazione:
P.C. Sham et al., "Power comparison of parametric and nonparametric linkage tests in small pedigrees", AM J HU GEN, 66(5), 2000, pp. 1661-1668

Abstract

When the mode of inheritance of a disease is unknown, the LOD-score methodof linkage analysis must take into account uncertainties in model parameters. We have previously proposed a parametric linkage test called "MFLOD," which does not require specification of disease model parameters. In the present study, we introduce two new model-free parametric linkage tests, knownas "MLOD" and "MALOD. " These tests are defined, respectively, as the LOD score and the admixture LOD score, maximized (subject to the same constraints as MFLOD) over disease-model parameters. We compared the power of these three parametric linkage tests and that of two nonparametric linkage tests, NPLall, and NPLpairs, which are implemented in GENEHUNTER. With the use of small pedigrees and a fully informative marker, we found the powers of MLOD, NPLall, and NPLpairs, to be almost equivalent to each other and not far below that of a LOD-score analysis performed under the assumption the correct genetic parameters. Thus, linkage analysis is not much hindered by uncertain mode of inheritance. The results also suggest that both parametric and nonparametric methods are suitable for linkage analysis of complex disorders in small pedigrees. However, whether these results apply to large pedigrees remains to be answered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:17:31