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Titolo:
Hazelnut allergy. Validation of diagnostic procedures on the basis of double-blind placebo-controlled food challenges
Autore:
Ballmer-Weber, BK; Vieths, S; Bucher, C; Luttkopf, D; Wuthrich, B;
Indirizzi:
Univ Zurich Hosp, Dermatol Klin, Allergiestn, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
ALLERGOLOGIE
fascicolo: 6, volume: 23, anno: 2000,
pagine: 285 - 291
SICI:
0344-5062(200006)23:6<285:HAVODP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Soggetto:
POLLEN; IGE; HYPERSENSITIVITY; FREQUENCY; SYMPTOMS; PEANUT; ATOPY;
Keywords:
hazelnut; allergy; double-blind placebo-controlled food challenge; oral allergy syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ballmer-Weber, BK Univ Zurich Hosp, Dermatol Klin, Allergiestn, Gloriastr 31, CH-8091 Zurich, Switzerland Univ Zurich Hosp Gloriastr 31 Zurich Switzerland CH-8091
Citazione:
B.K. Ballmer-Weber et al., "Hazelnut allergy. Validation of diagnostic procedures on the basis of double-blind placebo-controlled food challenges", ALLERGOLOGI, 23(6), 2000, pp. 285-291

Abstract

Hazelnut is one of the most frequent causes of food allergy. The diagnosisis based on patient's history, detection of specific IgE (CAP) and positive skin prick test. However, the properly performed double-blind, placebo-controlled food challenge (DBPCFC) is the only scientifically accepted test for the confirmation of food allergy. Other diagnostic methods can be validated only in patients, in whom allergy was confirmed by DBPCFC. So far, DBPCFC with hazelnut has never been performed. In this study, 23 patients with the history of an allergy to hazelnut underwent DBPCFC. Furthermore, skin prick tests with different hazelnut and pollen extracts, determination of specific IgE to hazelnut, to pollen from hazel and birch, and to the main birch allergens Bet v 1 and Bet v 2 were performed. Nineteen patients showed apositive DBPCFC. All of them complained about an oral allergy syndrome. Inaddition, one patient suffered from rhinoconjunctivitis with a delay of 4 hours. All patients were sensitized to pollen from hazel and birch and to Bet v 1. Just 5 patients showed specific IgE to Bet v 2. The sensitivity of skin prick test for hazelnut proved to be in these patients 84 - 95% (depending on the extract). The sensitivity for the determination of specific IgE(CAP) was 79%. In conclusion, skin prick test and CAP method proved to be in conjunction with the case history quite reliable for the diagnosis of allergy to hazelnut.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 23:40:24