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Titolo:
Intrathecal adenosine administration in abdominal hysterectomy lacks analgesic effect
Autore:
Rane, K; Sollevi, A; Segerdahl, M;
Indirizzi:
Danderyd Hosp, Dept Anaesthesia & Intens Care, S-18288 Danderyd, Sweden Danderyd Hosp Danderyd Sweden S-18288 ens Care, S-18288 Danderyd, Sweden Huddinge Univ Hosp, S-14186 Huddinge, Sweden Huddinge Univ Hosp HuddingeSweden S-14186 osp, S-14186 Huddinge, Sweden
Titolo Testata:
ACTA ANAESTHESIOLOGICA SCANDINAVICA
fascicolo: 7, volume: 44, anno: 2000,
pagine: 868 - 872
SICI:
0001-5172(200008)44:7<868:IAAIAH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
R-PHENYLISOPROPYL-ADENOSINE; RAT SPINAL-CORD; NEUROPATHIC PAIN; INFUSION; RECEPTORS; INJECTION; PHARMACOLOGY; ISOFLURANE; ALLODYNIA; AGONISTS;
Keywords:
anesthetic requirement; postoperative visceral pain; patient-controlled analgesia (PCA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Segerdahl, M Danderyd Hosp, Dept Anaesthesia & Intens Care, S-18288 Danderyd, Sweden Danderyd Hosp Danderyd Sweden S-18288 8288 Danderyd, Sweden
Citazione:
K. Rane et al., "Intrathecal adenosine administration in abdominal hysterectomy lacks analgesic effect", ACT ANAE SC, 44(7), 2000, pp. 868-872

Abstract

Background: Adenosine (Ado) is known, from studies in both animals and humans, to produce antinociception when administered systemically or intrathecally (IT). The current aim was to evaluate, in a placebo-controlled, randomised, double-blind study, whether IT adenosine given before surgery could reduce anaesthetic requirement and the need of opioids during 48 h after visceral surgery. Method: Forty women (37-66 years, ASA I and Il) scheduled for elective hysterectomy were included. Before inducing the standardised O-2/N2O/isoflurane/fentanyl anaesthesia, the patients received an IT injection of either adenosine (500 mu g in 1 mi volume) or placebo I mi (saline). Intraoperative anaesthetic drug doses and haemodynamics were recorded. Postoperative pain was assessed by visual analogue scale. For postoperative analgesia, cetobemidone was provided via intravenous patient-controlled analgesia (PCA). Results: During surgery, there were no differences between groups in anaesthetic requirement or haemodynamic parameters. Postoperative cetobemidone requirements were similar in bath groups (median 48 mg for adenosine/50 mg for saline) during the first 48 postoperative hours. Conclusion: IT adenosine did not influence the requirement of anaesthetic drug or postoperative analgesics after hysterectomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:17:50