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Titolo:
Differentiated thyroid cancer: "Complete" rational approach
Autore:
Kebebew, E; Clark, OH;
Indirizzi:
Univ Calif San Francisco, Mt Zion Med Ctr, Dept Surg, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sch Med, Dept Surg, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
WORLD JOURNAL OF SURGERY
fascicolo: 8, volume: 24, anno: 2000,
pagine: 942 - 951
SICI:
0364-2313(200008)24:8<942:DTC"RA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RET/PTC ONCOGENE ACTIVATION; SERUM THYROGLOBULIN LEVELS; ADENYLATE-CYCLASE ACTIVITY; PROGNOSTIC SCORING SYSTEM; HURTHLE CELL-CARCINOMA; LYMPH-NODE METASTASIS; NUCLEAR-DNA CONTENT; FOLLOW-UP; FOLLICULAR CARCINOMA; PAPILLARY CARCINOMA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, OH Univ Calif San Francisco, Mt Zion Med Ctr, Dept Surg, 1600 Divisadero St, San Francisco, CA 94143 USA Univ Calif San Francisco 1600 Divisadero St San Francisco CA USA 94143
Citazione:
E. Kebebew e O.H. Clark, "Differentiated thyroid cancer: "Complete" rational approach", WORLD J SUR, 24(8), 2000, pp. 942-951

Abstract

Controversy continues regarding the optimal management of patients with differentiated thyroid cancer because no prospective randomized studies evaluating the merits of (1) extent of thyroidectomy, (2) postoperative radioactive iodine ablation, or (3) thyroid-stimulating hormone (TSH) suppressive therapy exist. Patients with low risk differentiated thyroid cancer enjoy a relatively good prognosis,vith a mortality rate of about 2% to 5% and a recurrence rate of about 20%. Despite the excellent prognosis in patients considered to be at low risk, total or near-total thyroidectomy in patients with differentiated thyroid cancer has the advantages that: (1) postoperative radioactive iodine can be used to detect and treat residual normal thyroid tissue and local or distant metastases; (2) follow-up serum thyroglobulin levels are a more sensitive marker of persistent or recurrent disease when all thyroid tissue has been removed; and (3) total or near-total thyroidectomy,vith postoperative I-131 ablation and TSH suppressive therapy is associated with better survival and lower recurrence rates. Patients with occult papillary thyroid cancer and minimally invasive follicular thyroid cancer can be treated by thyroid lobectomy because they have a near-normal life expectancy. Virtually all other patients with differentiated thyroid cancer appear to benefit from more extensive initial treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:07:54