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Titolo:
Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model
Autore:
Richter, S; Yamauchi, J; Minor, T; Menger, MD; Vollmar, B;
Indirizzi:
Univ Saarlandes, Inst Clin & Expt Surg, D-66421 Homburg, Germany Univ Saarlandes Homburg Germany D-66421 t Surg, D-66421 Homburg, Germany
Titolo Testata:
TRANSPLANT INTERNATIONAL
fascicolo: 3, volume: 13, anno: 2000,
pagine: 225 - 229
SICI:
0934-0874(200005)13:3<225:HAPCRT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-TRANSPLANTATION; WARM ISCHEMIA; PREHEPARINIZATION; RESUSCITATION; PERFUSION;
Keywords:
non-heart-beating donors; liver; microvascular preservation; heparin; phentolamine; warm ischemia time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Vollmar, B Univ Saarlandes, Inst Clin & Expt Surg, D-66421 Homburg, Germany Univ Saarlandes Homburg Germany D-66421 6421 Homburg, Germany
Citazione:
S. Richter et al., "Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model", TRANSPLAN I, 13(3), 2000, pp. 225-229

Abstract

Improvement of organ procurement from non-heart-beating donors (NHBDs) could increase the donor organ pool for liver transplantation. Whether anti-coagulative and anti-vasospastic substances can improve hepatic microvascularpreservation from NHBDs is unknown. In donor rats which were pretreated with either heparin (n = 6) or heparin combined with phentolamine (n = 7) 10 min prior to cardiac arrest, the extent and homogeneity of hepatic microvascular reperfusion was assessed at the end of a 60-min period of cardiac arrest using in situ fluorescence microscopy Non-pretreated animals with cardiac arrest for 60 min served as controls (n = 6). In the non-treated NHBDs, arterial gravity perfusion of 100 cm H2O with HTK-solution led to a hepaticacinar reperfusion of only similar to 22% with a remarkably diminished sinusoidal density. Application of heparin prior to cardiac arrest resulted ina two-fold, but insignificant increase of acinar perfusion and sinusoidal density with a still considerable heterogeneity of both parameters. Livers of NHBDs that additionally received phentolamine exhibited significantly increased values of both acinar perfusion and sinusoidal density. Phentolamine was found to reduce heterogeneity of organ microperfusion. Thus, our results indicate that the combined application of heparin and phentolamine is auseful additive for optimizing the quality of organs harvested from NHBDs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:03:07