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Titolo:
Total synthesis of RS-42358 and analogs using lateral lithiation
Autore:
Kowalczyk, BA;
Indirizzi:
Roche Biosci, Chem Dev, Palo Alto, CA 94304 USA Roche Biosci Palo Alto CAUSA 94304 ci, Chem Dev, Palo Alto, CA 94304 USA
Titolo Testata:
SYNTHESIS-STUTTGART
fascicolo: 8, , anno: 2000,
pagine: 1113 - 1116
SICI:
0039-7881(200007):8<1113:TSORAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYSUBSTITUTED AROMATICS; ASYMMETRIC SUBSTITUTIONS; RECEPTOR ANTAGONISTS; (-)-SPARTEINE; PALONOSETRON; POTENT;
Keywords:
lateral lithiation; 5-HT3 receptor antagonist; RS-42358;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kowalczyk, BA Roche Biosci, Chem Dev, 3401 Hillview Ave, Palo Alto, CA 94304 USA Roche Biosci 3401 Hillview Ave Palo Alto CA USA 94304 04 USA
Citazione:
B.A. Kowalczyk, "Total synthesis of RS-42358 and analogs using lateral lithiation", SYNTHESIS-S, (8), 2000, pp. 1113-1116

Abstract

A short synthesis of the 5-HT3 receptor antagonist RS-42358 was developed based on the condensation of lactone 2 with S-3-aminoquinuclidine. The position 2 analogs of RS-42358 were made by condensing various primary amines with lactone 2. The key step in the synthesis of lactone 2 was lateral lithiation of diethyl amide 7 using n-BuLi in THF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:05:35