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Titolo:
A review of the literature for whole-body FDG PET in the management of patients with melanoma
Autore:
Schwimmer, J; Essner, R; Patel, A; Jahan, SA; Shepherd, JE; Park, K; Phelps, ME; Czernin, J; Gambhir, SS;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Crump Inst Biol Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Div Nucl Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA JWCI, Div Surg Oncol, Santa Monica, CA USA JWCI Santa Monica CA USAJWCI, Div Surg Oncol, Santa Monica, CA USA
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 44, anno: 2000,
pagine: 153 - 167
SICI:
1125-0135(200006)44:2<153:AROTLF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; LYMPH-NODE METASTASES; ALPHA-METHYL-TYROSINE; MALIGNANT-MELANOMA; F-18 FLUORODEOXYGLUCOSE; GLUCOSE-METABOLISM; UVEAL MELANOMA; BRAIN-TUMORS; FOLLOW-UP; MONOCLONAL-ANTIBODIES;
Keywords:
tomography, emission computed; fludeoxy-glucose F18; melanoma secondary; neoplasm recurrence, local;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Gambhir, SS Univ Calif Los Angeles, Sch Med, Crump Inst Biol Imaging, A-222B JLNRC,700Westwood Plaza,Box 951770, Los Angeles, CA 90095 USA Univ CalifLos Angeles A-222B JLNRC,700 Westwood Plaza,Box 951770 Los Angeles CA USA 90095
Citazione:
J. Schwimmer et al., "A review of the literature for whole-body FDG PET in the management of patients with melanoma", Q J NUCL M, 44(2), 2000, pp. 153-167

Abstract

Background. A review and meta-analysis of the literature on the use of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the detection of recurrent melanoma was conducted. The goals were to evaluatethe quality of data reporting and to determine the overall values for the sensitivity and specificity of whole body FDG PET and management changes. Methods. Guidelines to evaluate reporting within articles were formulated based on the United States medical payer source criteria for assessing studies reporting information on the utilization of new medical technology. A meta-analysis was conducted using methodology described in the peer reviewedliterature. Results. Our MEDLINE PLUS search resulted in a universe of 89 total articles. Within these 89, 19 were categorized in our targeted content area of which 13 were selected for analysis in our targeted subset, with the remaining 70 covering 24 different related content areas. Five of 13 (38%) articlesin the target subset reported data which was adequate for incorporation into modeling objectives based on PET sensitivity and specificity values, with 1 of 13 (8%) in the same target subset reporting data adequate for modeling based on change-in-management data. Through a meta-analysis of the 13 target articles we determined, within a 95% confidence level, an overall sensitivity of 92% (95% confidence level 88.41%-95.82%) and an overall specificity of 90% (95% confidence level 83.26%-96.05%) as calculated by number of lesions, for FDG PET detecting recurrent melanoma throughout the whole body. Furthermore, limited data available for change-in-management suggests an overall FDG PET directed change-in-management value of 22%. Conclusions. Our review suggests that improvements can be made to more effectively report the results of these FDG PET studies. The overall values determined through the meta-analysis indicate the potential benefits of usingFDG PET as a diagnostic/management tool Furthermore, these values should prove useful to assessing the cost effectiveness of utilizing FDG PET in themanagement of recurrent melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:56:18