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Titolo:
Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice
Autore:
Arai, I; Tsuyuki, Y; Shiomoto, H; Satoh, M; Otomo, S;
Indirizzi:
Taisho Pharmaceut Co Ltd, Self Medicat Labs, Pharmacol Evaluat, Ohmiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Ohmiya Saitama Japan 3308530tama 3308530, Japan
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 2, volume: 42, anno: 2000,
pagine: 171 - 176
SICI:
1043-6618(200008)42:2<171:DBTDAO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-DEPRESSANTS; ANTIDEPRESSANT TREATMENTS; ACID-SECRETION; ANIMAL-MODEL; RATS; STRESS; IMMOBILITY; RESTRAINT; DURATION; ULCER;
Keywords:
forced swimming test; body temperature; brain blood flow; brain glucose metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, I Taisho Pharmaceut Co Ltd, Self Medicat Labs, Pharmacol Evaluat, 1-403 Yoshino Cho, Ohmiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd 1-403 Yoshino Cho Ohmiya Saitama Japan 3308530
Citazione:
I. Arai et al., "Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice", PHARMAC RES, 42(2), 2000, pp. 171-176

Abstract

Effects of body temperature on the immobile response and brain glucose metabolism were examined in the forced swimming test in mice. The first experiment was performed to study behavior, after initial periods of vigorous activity, a characteristic immobile posture occurred when the water was 25 and35 degrees C. However, several minutes after forced swimming at 25 degreesC, significantly decreased spontaneous motility occurred in a time-dependent manner, but no changes was observed at 35 degrees C. Our interpretation was that mechanisms of acquisition and retention of the forced swim-inducedimmobile response differed. Body temperature was also significantly decreased at 25 degrees C but not at 35 degrees C in the forced swimming test. This lowering of body temperature almost paralleled the immobile response. The second experiment was a biochemical study in which the uptake of [C-14] 2-deoxy-D-glucose into the brain significantly decreased after forced swimming at 25 degrees C but did not change in the forced swim loaded mice when the water was 35 degrees C. These results suggested two types of immobile mechanisms in the forced swimming test: (1) an early phase acquisition of theimmobile response which might be related to adaptive response and (2) a late phase to retain the immobile response which might be related to the decrease in brain glucose metabolism. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:21:30