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Titolo:
L-sulpiride, at antidepressant dosage, prevents conditioned-fear stress-induced gastric lesions in rats
Autore:
Benelli, A; De Pol, A; Poggioli, R; Cavazzuti, E; Arletti, R; Bertolini, A; Vergoni, AV;
Indirizzi:
Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy Univ Modena, Dept Morphol & Legal Med Sci, Sect Histol Embryol & Genet, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 Embryol & Genet, I-41100 Modena, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 2, volume: 42, anno: 2000,
pagine: 157 - 160
SICI:
1043-6618(200008)42:2<157:LAADPC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIOR;
Keywords:
uncontrollable stress; gastric lesions; antidepressants; L-sulpiride; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Benelli, A Univ Modena, Dept Biomed Sci, Pharmacol Sect, Via Campi 287, I-41100 Modena, Italy Univ Modena Via Campi 287 Modena Italy I-41100 0 Modena, Italy
Citazione:
A. Benelli et al., "L-sulpiride, at antidepressant dosage, prevents conditioned-fear stress-induced gastric lesions in rats", PHARMAC RES, 42(2), 2000, pp. 157-160

Abstract

It has been previously shown that long-term treatment with low doses of L-sulpiride is highly effective in rat models of depression and of anticipatory anxiety/panic behavior. The present study was aimed at investigating whether the same treatment can prevent the ulcerogenic effect of repeated inescapable stresses. In adult rats, the repeated (7 consecutive days) exposureto an uncontrollable stressful condition (inescapable 2.5 mA scrambled shock for 60 s) produced the development of gastric lesions (multiple punctiform telangiectasias in all rats, with superficial erosions or more severe ulcerations in 10 out 13 rats; score 4.67 +/- 0.44). L-sulpiride, intraperitoneally injected once a day at an antidepressant dose level (4 mg kg(-1) perday), starting 21 days before the beginning of the 7-day sequence of inescapable punishments (= 28 daily treatments), almost completely prevented thestress-induced gastric injury (score 1.67 +/- 0.29; P < 0.001 vs saline-treated rats, Mann-Whitney U test). These results show that, in rats, a long-term treatment with low doses of L-sulpiride prevents the development of gastric lesions induced by chronic exposure to uncontrollable stress. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:33:17