Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ASSOCIATION OF POORLY CONTROLLED DIABETES WITH LOW SERUM LEPTIN IN MORBID-OBESITY
Autore:
CLEMENT K; LAHLOU N; RUIZ J; HAGER J; BOUGNERES P; BASDEVANT A; GUYGRAND B; FROGUEL P;
Indirizzi:
INST PASTEUR,CNRS,EP 10,1 RUE CALMETTE,BP 245 F-59019 LILLE FRANCE INST PASTEUR,CNRS,EP 10 F-59019 LILLE FRANCE HOP HOTEL DIEU,SERV NUTR PARIS FRANCE CHU LILLE F-59019 LILLE FRANCE CHU VAUDOIS,DEPT MED INTERNE,DIV ENDOCRINOL & METAB CH-1011 LAUSANNE SWITZERLAND HOP ST VINCENT DE PAUL,INSERM,U342 F-75674 PARIS FRANCE
Titolo Testata:
International journal of obesity
fascicolo: 7, volume: 21, anno: 1997,
pagine: 556 - 561
SICI:
0307-0565(1997)21:7<556:AOPCDW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; INSULIN; WEIGHT; EXPRESSION; PROTEIN;
Keywords:
LEPTIN; HYPERGLYCEMIA; MORBID OBESITY; NIDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K. Clement et al., "ASSOCIATION OF POORLY CONTROLLED DIABETES WITH LOW SERUM LEPTIN IN MORBID-OBESITY", International journal of obesity, 21(7), 1997, pp. 556-561

Abstract

OBJECTIVES: Leptin may be involved in the regulation of body weight, food intake, and energy expenditure. In view of a possible link between leptin concentrations and diabetes that has been suggested in obese rodents, we investigated the potential relationship between serum leptin concentrations and hyperglycaemia in French patients with morbid obesity. SUBJECTS: Fasting leptin concentrations were measured in 241 morbidity obese patients with various degrees of glucose tolerance in a cross-sectional study. RESULTS: fasting serum leptin concentrations did not differ between normoglycaemic (NG, 61.5 +/- 24.0 ng/ml) and glucose intolerant morbidly obese subjects (IGT, 56.5 +/- 18.5 ng/ml) and were slightly lower in those with controlled diabetes (55.1 +/- 30.3 ng/ml, P = 0.06 when compared to NG subjects). In contrast, leptin concentrations were 30%, lower in patients with poorly controlled diabetes(43.0 +/- 22.2 ng/ml, P = 0.001 vs NG subjects). Leptin concentrations were negatively correlated with fasting glucose in all groups combined (rho = -0.24, P = 0.0001) and particularly in NIDDM subjects (rho =0.31, P = 0.0054). Although leptin concentrations were higher in women than Inn men, similar significant correlation with fasting glucose was found when females were analyzed separately. A positive correlationwas found with BMI (rho = 0.25, P = 0.0001) in all groups. Multivariate analysis revealed that fasting glucose was Independently associatedwith serum leptin concentrations (F = 12.5, P = 0.0005). Sex, age, BMI, waist/hip ratio, fasting glucose and insulin, Petal cholesterol andtriglycerides, tested in the model, explained 42% of the leptin variability in this population. CONCLUSIONS: poorly controlled diabetes wasaccompanied by a significant reduction of serum leptin concentrationsin morbidly obese subjects. We suggest that a relative leptin deficiency (lower than expected for the BMI) associated with insulin deficiency In this population might contribute to a vicious cycle maintaining (or even worsening) obesity itself and/or its metabolic complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:01:25