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Titolo:
TS plus OCD-like neuropotentiated mice are supersensitive to seizure induction
Autore:
Campbell, KM; Veldman, MB; McGrath, MJ; Burton, FH;
Indirizzi:
Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 11, anno: 2000,
pagine: 2335 - 2338
SICI:
0959-4965(20000714)11:10<2335:TPONMA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; TRANSGENIC MOUSE MODEL; PIRIFORM CORTEX; RAT; EXPRESSION; RECEPTORS; NEURONS; LOCALIZATION; STIMULATION; PILOCARPINE;
Keywords:
amygdala; cholera toxin; compulsions; D1 receptor; epilepsy; glutamate; insular; piriform; somatosensory; tics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Burton, FH Univ Minnesota, Dept Pharmacol, 6-120 Jackson Hall,321 Church St SE, Minneapolis, MN 55455 USA Univ Minnesota 6-120 Jackson Hall,321 Church St SE Minneapolis MN USA 55455
Citazione:
K.M. Campbell et al., "TS plus OCD-like neuropotentiated mice are supersensitive to seizure induction", NEUROREPORT, 11(10), 2000, pp. 2335-2338

Abstract

Seizures can be induced by systemic dopamine D1 receptor agonists or by cortical-limbic neurostimulation non-selectively. Seizures are also often associated with ties and compulsions, which likewise involve cortical-limbic hyperactivity. To determine if selective potentiation of cortical-limbic D1 receptor-expressing (DIS) neurons increases seizure susceptibility, we administered pentylenetetrazole (PTZ) to mice that express a neuropotentiating transgene only in a glutamatergic, cortical-limbic subset of D1+ neurons (D1CT-7 line). These mice exhibited increased PTZ-dependent seizure incidence, onset rate and intensity. Because D1CT-7 mice also exhibit tic+compulsion-like behaviors, this implies that glutamatergic hyperactivity induced by cortical-limbic D1+ neuropotentiation facilitates not only epilepsy but alsoties and compulsions. This suggests a dopamine-regulated glutamatergic basis for all three states and may explain why they often co-exist in humans. NeuroReport 11:2335-2338 (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 04/04/20 alle ore 08:52:53