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Titolo:
The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system
Autore:
Joyce, JN; Yoshimoto, K; Ueda, S;
Indirizzi:
Sun Hlth Res Inst, Thomas H Christopher Ctr Parkinsons Dis Res, Sun City, AZ 85351 USA Sun Hlth Res Inst Sun City AZ USA 85351 s Dis Res, Sun City, AZ 85351 USA Kyoto Prefectural Univ Med, Dept Legal Med, Kamikyo Ku, Kyoto 6010841, Japan Kyoto Prefectural Univ Med Kyoto Japan 6010841 Ku, Kyoto 6010841, Japan Dokkyo Univ, Sch Med, Dept Histol & Neurobiol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 biol, Mibu, Tochigi 3210293, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 11, anno: 2000,
pagine: 2173 - 2175
SICI:
0959-4965(20000714)11:10<2173:TZMREL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-3 RECEPTOR; PARKINSONS-DISEASE; STRIATAL DOPAMINE; EXPRESSION; BRAIN; NEURONS; MONKEY; MPTP;
Keywords:
nucleus accumbens; Parkinson's disease; radioligand assay; striatum; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Joyce, JN Sun Hlth Res Inst, Thomas H Christopher Ctr Parkinsons Dis Res, Sun City, AZ 85351 USA Sun Hlth Res Inst Sun City AZ USA 85351 Sun City, AZ 85351 USA
Citazione:
J.N. Joyce et al., "The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system", NEUROREPORT, 11(10), 2000, pp. 2173-2175

Abstract

Experimental studies of the regulation of the dopamine (DA) D-3 receptor have utilized techniques causing massive depletions of the DA system. Zittermutant rats exhibiting a heterogeneous loss of striatal DA innervation were examined for DA transporter (DAT) binding and DA D-3 receptor number by autoradiography and compared with Sprague-Dawley rats. A significant loss ofDAT binding was observed with the greatest in the lateral caudate-putamen (72% loss) and the least in the nucleus accumbens (45% loss). DA D-3 receptors were reduced by >70% in all regions, even in the nucleus accumbens thatexhibited considerably smaller depletions of DAT binding, indicating that loss of D-3 receptors may occur prior to massive loss of DA innervation. NeuroReport 11:2173-2175 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:31:52