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Titolo:
Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficitsassociated with NMDA receptor antagonism
Autore:
Zhang, HT; Crissman, AM; Dorairaj, NR; Chandler, LJ; ODonnell, JM;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ut, Shreveport, LA 71130 USA Med Univ S Carolina, Dept Physiol, Ctr Drug & Alcohol Programs, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 ams, Charleston, SC 29425 USA Med Univ S Carolina, Dept Neurosci & Psychiat, Ctr Drug & Alcohol Programs, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 ams, Charleston, SC 29425 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 23, anno: 2000,
pagine: 198 - 204
SICI:
0893-133X(200008)23:2<198:IOCAP(>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RADIAL-ARM MAZE; INDUCED IMPAIRMENTS; SPATIAL WORKING; CAMP RESPONSE; RAT-BRAIN; AREA CA1; ROLIPRAM; HIPPOCAMPUS; PERFORMANCE;
Keywords:
rolipram; MK-801; cyclic AMP; phosphodiesterase; NMDA receptor; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, HT Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 port, LA 71130 USA
Citazione:
H.T. Zhang et al., "Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficitsassociated with NMDA receptor antagonism", NEUROPSYCH, 23(2), 2000, pp. 198-204

Abstract

Rolipram, a selective inhibitor of type 4 cyclic AMP phosphodiesterase (PDE4), completely reversed the amnesic effects of MK-801 on working and reference memory (F[4,64] = 11.10; p < .0001 and F[4,64] = 2.53; p < .05, respectively) at doses of 0.01-0.1 mg/kg ill the radial-arm maze task. Similar antagonism by rolipram of the effects of MK-801 was observed oil inhibitory avoidance behavior (F[3,35] = 190.8; p < .0001). In vitro evidence suggests that an increase ill cAMP concentrations may mediate the observed behavioral effects of rolipram. In the absence of PDE4 inhibition, NMDA did not increase cAMP concentrations in primary cultures of rat cerebral cortical neurons. However, when PDE4 was inhibited with rolipram, NMDA markedly elevated cAMP. These observations suggest that PDE4 is all integral component of theNMDA receptor-mediated signal transduction pathway involved in memory processes. Inhibitors of PDE4 may act on this pathway to produce their effects on memory and may represent a new class of cognitive enhancers. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

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Documento generato il 02/12/20 alle ore 17:50:25