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Titolo:
The latent inhibition model dissociates between clozapine, haloperidol, and ritanserin
Autore:
Shadach, E; Gaisler, I; Schiller, D; Weiner, I;
Indirizzi:
Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 sychol, IL-69978 Tel Aviv, Israel
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 23, anno: 2000,
pagine: 151 - 161
SICI:
0893-133X(200008)23:2<151:TLIMDB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC OLANZAPINE; SCHIZOPHRENIC ATTENTION DISORDER; AMPHETAMINE-INDUCED DISRUPTION; INDUCED STEREOTYPED BEHAVIOR; SOCIAL-ISOLATION; SWITCHING MODEL; HEALTHY PEOPLE; IN-VITRO; RATS; DRUGS;
Keywords:
latent inhibition; clozapine; haloperidol; ritanserin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, I Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 -69978 Tel Aviv, Israel
Citazione:
E. Shadach et al., "The latent inhibition model dissociates between clozapine, haloperidol, and ritanserin", NEUROPSYCH, 23(2), 2000, pp. 151-161

Abstract

Latent inhibition (LI), i.e., retarded conditioning to a stimulus following its nonreinforced preexposure, is impaired in some subsets of schizophrenia patients and in amphetamine-treated mts. Typical and atypical antipsychotic drugs (APD's) potentiate LI, but to date the model has not dissociated between them. This study demonstrates such a dissociation using haloperidol(0.1 mg/kg), clozapine (5 mg/kg), anti ritanserin (0.6 mg/kg) administeredin preexposure and/or conditioning. Under conditions which did not yield LI in vehicle controls 140 preexposures and five conditioning trials), both haloperidol and clozapine, but not ritanserin, led to LI when administered in conditioning. Under conditions which led lo LI in vehicle controls (40 preexposures and two conditioning trials), clozapine and ritanserin, but nothaloperidol, abolished LI when administered in preexposure. It is suggested that LI potentiation via conditioning detects Nle "typical" action of APDS whereas LI disruption via preexposure detects the "atypical" action of APD's. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:18:41