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Titolo:
Human research on MDMA (3,4-methylenedioxymethamphetamine) neurotoxicity: Cognitive and behavioural indices of change
Autore:
Parrott, AC;
Indirizzi:
Univ E London, Dept Psychol, London E15 4LZ, England Univ E London London England E15 4LZ pt Psychol, London E15 4LZ, England
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 1, volume: 42, anno: 2000,
pagine: 17 -
SICI:
0302-282X(2000)42:1<17:HROM(N>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECSTASY MDMA; RECREATIONAL USERS; MEMORY DEFICITS; PHARMACOLOGY; SEQUELAE; NEURONS; MOOD;
Keywords:
MDMA (3,4-methylenedioxymethamphetamine) ecstasy; serotonin; cognition; memory; impulsivity; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Parrott, AC Univ E London, Dept Psychol, London E15 4LZ, England Univ E London London England E15 4LZ London E15 4LZ, England
Citazione:
A.C. Parrott, "Human research on MDMA (3,4-methylenedioxymethamphetamine) neurotoxicity: Cognitive and behavioural indices of change", NEUROPSYCHB, 42(1), 2000, pp. 17

Abstract

Laboratory animals can develop serotonergic neurotoxicity after repeated doses of 3,4-methylenedioxymethamphetamine (MDMA) or 'Ecstasy', If similar neural damage occurs in humans, this may be evident in cognitive or behavioural impairments. In a review of the behavioural skills shown by drug-free recreational Ecstasy users, three aspects of cognitive performance are oftenaffected: reduced memory for new information (Rivermead Behavioral Memory,supraspan word recall), impaired higher executive processing (Wisconsin Card Sort, Tower of London), and heightened impulsivity (Impulsiveness, Venturesomeness and Empathy Questionnaire, Matching Familiar Figures test). Performance on other more basic cognitive functions is generally unimpaired (simple reaction time, choice reaction time, number vigilance, Stroop, trail making). Some Ecstasy users also complain of poor memories and/or concentration difficulties, which they attribute to MDMA use. There are many methodological problems and uncertainties with research in this field: non-random allocation of subjects to drug conditions, the deleterious effects of other psychoactive drugs, and the possibility that these adverse profiles reflectpre-existing personality characteristics in Ecstasy users. However, this particular pattern of cognitive decrements in humans, is consistent with theanimal data on those brain areas showing serotonergic damage following MDMA: the frontal cortex (impulsivity and higher cognitive impairments), and hippocampus (memory deficits). Finally, this profile of cognitive deficits is also consistent with a hypothetical integrative construct: namely reducedcortical inhibition. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:54:02