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Titolo:
(+/-)3,4-methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Clinical studies
Autore:
McCann, UD; Eligulashvili, V; Ricaurte, GA;
Indirizzi:
Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA Johns Hopkins Sch Med Baltimore MD USA at & Behav Sci, Baltimore, MD USA Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA Johns Hopkins Sch Med Baltimore MD USA d, Dept Neurol, Baltimore, MD USA
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 1, volume: 42, anno: 2000,
pagine: 11 - 16
SICI:
0302-282X(2000)42:1<11:((SN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; MDMA ECSTASY; COGNITIVE PERFORMANCE; PROLACTIN SECRETION; HEALTHY CONTROLS; MEMORY DEFICITS; L-TRYPTOPHAN; HUMANS; USERS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE;
Keywords:
(+/-)3,4-methylenedioxymethamphetamine amphetamines; serotonin; neurotoxicity; neuroendocrine function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: McCann, UD Johns Hopkins Bayview Med Ctr, Behav Pharmacol Res Unit, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr, Baltimore, MD 21224 USA Johns Hopkins Bayview Med Ctr 5510 Nathan Shock Dr Baltimore MDUSA 21224
Citazione:
U.D. McCann et al., "(+/-)3,4-methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Clinical studies", NEUROPSYCHB, 42(1), 2000, pp. 11-16

Abstract

(+/-)3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy') is a brain serotonergic neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly popular recreational drug of abuse, and doses of MDMA th at a re used recreationally overlap with those that produce serotonin (5-HT) neurotoxicity in animals. Studies in human MDMA users probing for evidence of brain serotonergic neurotoxicity indicate that some MDMA users may incur MDMA-related 5-HT neural injury and, possibly, functional sequelae, In particular, MDMA users have selective decrements in cerebrospinal fluid 5-hydroxyindoleacetic acid and brain 5-HT transporters, similar to nonhuman primates with documented MDMA-induced neurotoxicity. Functional abnormalities seen in MDMA users that may be related to 5-HT injury include cognitive deficits, altered sleep architecture, altered neuroendocrine function, altered behavioral responses to 5-HT selective drugs, and increased impulsivity. Additional studies in animals, as well as longitudinal and epidemiological studies in MDMA users, are required to confirm and extend the presentdata, and to determine whether MDMA users are at increased risk for developing neuropsychiatric illness as they age. Copyright (C) 2000 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:24:19