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Titolo:
The dopamine antagonist Sch 23390 reverses dizocilpine-induced blockade ofcocaine sensitization
Autore:
Parada, A; Soares-da-Silva, P;
Indirizzi:
BIAL, Dept Res & Dev, P-4785 S Mamede do Coronado, Portugal BIAL S Mamededo Coronado Portugal P-4785 S Mamede do Coronado, Portugal
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 9, volume: 39, anno: 2000,
pagine: 1645 - 1652
SICI:
0028-3908(2000)39:9<1645:TDAS2R>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; RAT NUCLEUS-ACCUMBENS; D-ASPARTATE ANTAGONISTS; BEHAVIORAL SENSITIZATION; RECEPTOR ANTAGONISTS; AUTORECEPTOR SUBSENSITIVITY; EXTRACELLULAR DOPAMINE; AMPHETAMINE TREATMENT; LOCOMOTOR-ACTIVITY; NEURONAL-ACTIVITY;
Keywords:
cocaine sensitization; dizocilpine; D-1 receptors; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Soares-da-Silva, P BIAL, Dept Res & Dev, P-4785 S Mamede do Coronado, Portugal BIAL S Mamede do Coronado Portugal P-4785 o, Portugal
Citazione:
A. Parada e P. Soares-da-Silva, "The dopamine antagonist Sch 23390 reverses dizocilpine-induced blockade ofcocaine sensitization", NEUROPHARM, 39(9), 2000, pp. 1645-1652

Abstract

The present work examined the effects of pre-treatment with Sch 23390, a selective D-1 receptor antagonist, on the dizocilpine-induced blockade of sensitization to the locomotor-stimulating effect of cocaine. Rats were giveneither cocaine [15 mg kg(-1) day(-1) intraperitoneally (i.p.)] from day 1 to day 5 (cocaine-experienced rats) or vehicle (cocaine-naive rats). From day 6 to day 15, animals remained drug-free in their home cages. On day 16 rats received a challenge injection of cocaine (15 mg kg(-1)) or vehicle, and were tested for sensitization to the locomotor-stimulating effect of cocaine. In cocaine-naive rats the acute effect of cocaine was a 1.5 times increase in locomotor activity. In cocaine-experienced rats, the acute effects of cocaine were considerably more pronounced than in cocaine-naive rats; the stimulating effect of cocaine in these animals was a doubling in locomotor activity. In cocaine-naive rats, pre-treatment with dizocilpine (100 mu gkg(-1)), Sch 23390 (100 mu g kg(-1)) or a combination of the two drugs from day 1 to day 5 changed neither spontaneous locomotor activity nor cocainestimulant activity. By contrast, cocaine-experienced animals that had beengiven 100 mu g kg-(1) dizocilpine from day 1 to day 5 failed to show the increase in locomotor activity when challenged with cocaine on day 16. Pre-treatment with Sch 23390 (100 mu g kg(-1)day(-1), i.p.) from day 1 to day 5 was found to prevent completely the cocaine anti-sensitization properties of 100 mu g kg(-1) dizocilpine, but failed to prevent cocaine sensitization. On the other hand, horizontal activity in cocaine-experienced rats that had been given dizocilpine (100 mu g kg(-1)) 15 min before cocaine challenge on day 16 was higher than in corresponding controls. It is concluded that prevention of cocaine sensitization by dizocilpine may be related to the events set into motion by the NMDA antagonist at the level of dopaminergic transmission involving D-1 receptors. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:41:46