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Titolo:
Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions
Autore:
Knobeloch, KP; Wright, MD; Ochsenbein, AF; Liesenfeld, O; Lohler, J; Zinkernagel, RM; Horak, I; Orinska, Z;
Indirizzi:
Free Univ Berlin, Inst Mol Pharmacol, Dept Mol Genet, D-12207 Berlin, Germany Free Univ Berlin Berlin Germany D-12207 l Genet, D-12207 Berlin, Germany Free Univ Berlin, Inst Infect Med, D-12207 Berlin, Germany Free Univ Berlin Berlin Germany D-12207 ect Med, D-12207 Berlin, Germany Free Univ Berlin, Benjamin Franklin Univ Hosp, D-12207 Berlin, Germany Free Univ Berlin Berlin Germany D-12207 iv Hosp, D-12207 Berlin, Germany Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-2000 Hamburg, Germany Univ Hamburg Hamburg Germany D-2000 l & Immunol, D-2000 Hamburg, Germany Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res Melbourne Vic Australia 3050 , Australia Univ Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8091 unol, CH-8091 Zurich, Switzerland
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 15, volume: 20, anno: 2000,
pagine: 5363 - 5369
SICI:
0270-7306(200008)20:15<5363:TIOTTC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MHC CLASS-II; INDEPENDENT ANTIGENS; MICE LACKING; ANTIBODY-PRODUCTION; IMMUNE-RESPONSES; BONE-MARROW; LYMPHOCYTES; MOLECULES; CD81; GLYCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Horak, I Free Univ Berlin, Inst Mol Pharmacol, Dept Mol Genet, Krahmerstr 6, D-12207 Berlin, Germany Free Univ Berlin Krahmerstr 6 Berlin Germany D-12207 in, Germany
Citazione:
K.P. Knobeloch et al., "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions", MOL CELL B, 20(15), 2000, pp. 5363-5369

Abstract

CD37 is a membrane protein of the tetraspanin superfamily, which includes CD9, CD53, CD63, CD81, and CD82, Many of these molecules are expressed on leukocytes and have been implicated in signal transduction, cell cell interactions, and cellular activation and development, We generated and analyzed mice deficient for CD37. Despite the high expression of CD37 on cells of the immune system, no changes in development and cellular composition of lymphoid organs were observed in mice lacking CD37, Analyses of humoral immune responses revealed a reduced level of immunoglobulin G1 (IgG1) in the sera of nonimmunized mice and an alteration of responses to T-cell-dependent antigens, Antibody responses to model antigen administered in the absence of adjuvant and to viral infections were generally poor in CD37-deficient mice. These poor antibody responses could be overcome by the immunization of antigen together with adjuvant, These results suggest a role for CD37 in T-cell-B-cell interactions which manifests itself under suboptimal costimulatoryconditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:42:58