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Titolo:
Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide
Autore:
Shimazu, T; Ikeuchi, H; Sugimoto, H; Goodwin, CW; Mason, AD; Pruitt, BA;
Indirizzi:
USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA USA Ft Sam Houston TX USA 78234 st Surg Res, Ft Sam Houston, TX 78234 USA Osaka Univ, Sch Med, Dept Traumatol, Osaka, Japan Osaka Univ Osaka Japan saka Univ, Sch Med, Dept Traumatol, Osaka, Japan
Titolo Testata:
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
fascicolo: 1, volume: 49, anno: 2000,
pagine: 126 - 131
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOKE-INHALATION INJURY; MODEL;
Keywords:
carbon monoxide; carboxy-hemoglobin (COHb); smoke inhalation injury; half-life; two compartment analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Shimazu, T USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston,TX 78234 USA USA 3400 Rawley E Chambers Ave Ft Sam Houston TX USA 78234 USA
Citazione:
T. Shimazu et al., "Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide", J TRAUMA, 49(1), 2000, pp. 126-131

Abstract

Background: In models of smoke inhalation injury and carbon monoxide poisoning blood carboxy-hemoglobin (COHb levels decrease faster than predicted by the generally recognized half-life of COHb. We studied the effects of duration of exposure to carbon monoxide (CO) on the subsequent CO elimination. Methods: Each of four sheep were insufflated with CO gas mixtures either for a few minutes (short-term exposure) or for several hours (long-term exposure), then ventilated with air for 3 hours. Serial COHb concentrations were analyzed by using a two-compartment, single central outlet mathematical model. Results: Short-term exposures exhibited biphasic decreases of COHb concentration compatible with a two-compartment model; an initial rapid decrease (half-life 5.7 +/- 1.4 minutes) was followed by a slower phase (103 +/- 20.5minutes). Long-term exposures exhibited almost monophasic decreases, whichwere nevertheless compatible with the model (half-life, 21.5 +/- 2.1 and 118 +/- 11.2 minutes). Conclusions: This study demonstrated different patterns of CO elimination curve, which suggests distribution of CO to two compartments having different rates of equilibration.

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Documento generato il 20/01/20 alle ore 16:19:57