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Titolo:
Neuronal morphology and the synaptic organisation of sympathetic ganglia
Autore:
Gibbins, IL; Jobling, P; Messenger, JP; Teo, EH; Morris, JL;
Indirizzi:
Flinders Univ S Australia, Ctr Neurosci, Dept Anat & Histol, Adelaide, SA 5001, Australia Flinders Univ S Australia Adelaide SA Australia 5001 , SA 5001, Australia
Titolo Testata:
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
fascicolo: 1-3, volume: 81, anno: 2000,
pagine: 104 - 109
SICI:
0165-1838(20000703)81:1-3<104:NMATSO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR MESENTERIC GANGLION; GUINEA-PIG; ULTRASTRUCTURAL ANALYSIS; VASOCONSTRICTOR NEURONS; DENDRITIC MORPHOLOGY; NEUROPEPTIDE CONTENT; PREGANGLIONIC AXONS; CELLS; INNERVATION; PILOMOTOR;
Keywords:
autonomic; neuropeptides; dendrites; ultrastructure; heterosynaptic transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Gibbins, IL Flinders Univ S Australia, Ctr Neurosci, Dept Anat & Histol, GPO Box 2100,Adelaide, SA 5001, Australia Flinders Univ S Australia GPO Box 2100 Adelaide SA Australia 5001
Citazione:
I.L. Gibbins et al., "Neuronal morphology and the synaptic organisation of sympathetic ganglia", J AUTON NER, 81(1-3), 2000, pp. 104-109

Abstract

In this article, we provide a short review of the structure and synaptic organisation of the final motor neurons in the sympathetic ganglia of mammals. Combinations of pathway tracing, multiple-labelling immunofluorescence and intracellular dye injection have shown that neurons in different functional pathways differ nor only in their patterns of neuropeptide expression, but also in the size of their cell bodies and dendritic fields. Thus, vasoconstrictor neurons consistently are smaller than any other major functionalclass of neurons. Serial section ultrastructural analysis of dye filled neurons, together with electron microscopic and confocal microscopic analysisof immunolabelled synaptic inputs to sympathetic final motor neurons indicate that synapses are rare and randomly distributed over the surface of theneurons. The total number of synapses is simply proportional to the total surface area of the neurons. Many terminal boutons of peptide-containing preganglionic neurons do nor make conventional synapses with target neurons. Furthermore, there is a spatial mismatch in the distribution of peptide-containing terminals and neurons expressing receptors for the corresponding peptides. Together, these results suggest that there are likely to be significant differences in the ways that the final sympathetic motor neurons in distinct functional pathways integrate their synaptic inputs, fn at least some pathways, heterosynaptic actions of neuropeptides probably contribute to subtle modulation of ganglionic transmission. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:37:29