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Titolo:
Types of neurons in the enteric nervous system
Autore:
Furness, JB;
Indirizzi:
Univ Melbourne, Dept Anat & Cell Biol, Parkville, Vic 3010, Australia UnivMelbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia
Titolo Testata:
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
fascicolo: 1-3, volume: 81, anno: 2000,
pagine: 87 - 96
SICI:
0165-1838(20000703)81:1-3<87:TONITE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG SMALL-INTESTINE; CYCLASE ACTIVATING PEPTIDE; INHIBITORY MOTOR-NEURONS; PRIMARY AFFERENT NEURONS; DOGIEL TYPE-II; GUINEA-PIG; CIRCULAR MUSCLE; MYENTERIC NEURONS; DISTAL COLON; NITRIC-OXIDE;
Keywords:
enteric nervous system; neurochemistry; intestine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Furness, JB Univ Melbourne, Dept Anat & Cell Biol, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 c 3010, Australia
Citazione:
J.B. Furness, "Types of neurons in the enteric nervous system", J AUTON NER, 81(1-3), 2000, pp. 87-96

Abstract

This paper, written for the symposium in honour of more than 40 years' contribution to autonomic research by Professor Geoffrey Burnstock, highlightsthe progress made in understanding the organisation of the enteric nervoussystem over this time. Forty years ago, the prevailing view was that the neurons within the gut wall were post-ganglionic neurons of parasympathetic pathways. This view was replaced as evidence accrued that the neurons are part of the enteric nervous system and are involved in reflex and integrative activities that can occur even in the absence of neuronal influence from extrinsic sources. Work in Burnstock's laboratory led to the discovery of intrinsic inhibitory neurons with then novel pharmacology of transmission, and precipitated investigation of neuron types in the enteric nervous system. All the types of neurons in the enteric nervous system of the small intestine of the guinea-pig have now been identified in terms of their morphologies, projections, primary neurotransmitters and physiological identification. In this region there are 14 functionally defined neuron types, each witha characteristic combination of morphological, neurochemical and biophysical properties, The nerve circuits underlying effects on motility, blood flow and secretion that are mediated through the enteric nervous system are constructed from these neurons. The circuits for simple motility reflexes arenow known, and progress has been made in analysing those involved in localcontrol of blood flow and transmucosal fluid movement in the small intestine. (C) 2000 Elsevier Science SN, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:40:41