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Titolo:
CHINESE ADULTS ARE LESS SUSCEPTIBLE THAN WHITES TO AGE-RELATED ENDOTHELIAL DYSFUNCTION
Autore:
WOO KS; MCCROHON JA; CHOOK P; ADAMS MR; ROBINSON JTC; MCCREDIE RJ; LAM CWK; FENG JZ; CELERMAJER DS;
Indirizzi:
ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL,MISSENDEN RD CAMPERDOWN NSW 2050 AUSTRALIA CHINESE UNIV HONG KONG,DEPT MED HONG KONG HONG KONG CHINESE UNIV HONG KONG,DEPT CHEM PATHOL HONG KONG HONG KONG GUANGDONG PROV CARDIOVASC INST GUANGZHOU PEOPLES R CHINA ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL SYDNEY NSW AUSTRALIA HEART RES INST SYDNEY NSW AUSTRALIA
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 1, volume: 30, anno: 1997,
pagine: 113 - 118
SICI:
0735-1097(1997)30:1<113:CAALST>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC CORONARY-ARTERIES; BLOOD-FLOW; DEPENDENT DILATION; HEART-DISEASE; RISK-FACTORS; ACETYLCHOLINE; CHOLESTEROL; RESPONSES; HUMANS; HYPERCHOLESTEROLEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Woo et al., "CHINESE ADULTS ARE LESS SUSCEPTIBLE THAN WHITES TO AGE-RELATED ENDOTHELIAL DYSFUNCTION", Journal of the American College of Cardiology, 30(1), 1997, pp. 113-118

Abstract

Objectives. We sought to assess the effects of aging on the endothelial physiology of a group of Chinese adults. Background. Several studies have documented an association between aging and progressive arterial endothelial dysfunction in white subjects. We hypothesized that age-related endothelial dysfunction, an important event in atherosclerosis, might be less marked in southern Chinese subjects, in whom the prevalence of coronary heart disease is only similar to 20% of that in industrialized countries. Methods. We studied endothelial function in 76 healthy adults aged 16 to 70 years: 38 Chinese from a village of 3,000 people in southern China and 38 white subjects from Sydney, Australia. In each ethnic group, there were 19 younger persons (16 to 40 years) and 19 older adults (55 to 70 years). None had evidence of diabetes, hypertension or clinical vascular disease or had ever been regular cigarette smokers. With the use of high resolution external vascular ultrasound, brachial artery diameter was measured at rest, after how increase (causing endothelium-dependent dilation) and after sublingual nitroglycerin (an endothelium-independent dilator). Results. Endothelium-dependent dilation was similar in young Chinese (mean +/- SD 8.3 +/- 2.5%), young whites (7.9 +/- 2.0%) and older Chinese (6.8 +/- 2.9%), but it was significantly impaired in alder whites (1.8 +/- 2.5%, p < 0.001by analysis of variance). On multivariate analysis, older age aas associated with impaired endothelium-dependent dilation (p < 0.001) (independent of the effects of serum cholesterol, gender and vessel size) in the white but not in the Chinese subjects (p = 0.83). Nitroglycerin-induced dilation was not significantly different with aging in either ethnic group. Conclusions. Endothelium-dependent dilation is similar in the arteries of healthy young Chinese and white adults. With older age, however, Chinese subjects are less susceptible to impaired endothelial function. (C) 1997 by the American College of Cardiology.

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Documento generato il 02/07/20 alle ore 21:25:10